{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:48:40Z","timestamp":1791499720591,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T00:00:00Z","timestamp":1574294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1053342"],"award-info":[{"award-number":["OPP1053342"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the acceptability and safety of thermal ablation (TA) for the treatment of precancerous cervical lesions in women in Honduras.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Human papillomavirus (HPV) and visual inspection with acetic acid (VIA) screen\u2010positive eligible women received TA. After treatment, women rated the level of pain experienced during treatment using the Wong\u2010Baker FACES\u00ae\u00a0pain\u2010rating scale from 0 to 10. Short\u2010term safety outcomes that could require medical attention were assessed one month after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 319 women received TA treatment. The average pain rating was 2.5 (95% CI: 2.3\u20132.8), and 85% rated their pain levels as less than 6. No significant differences in low (below 6) or high (6 and above) pain were found by age or number of biopsies performed, but there was a significant difference by the number of TA applications (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). When asked if they would recommend this treatment, all women said they would. At the one\u2010month follow\u2010up visit, the most common reported discomforts were bleeding (10%) and cramping (8.4%); 11 women reported severe lower abdominal pain, and none required medical attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TA is safe and acceptable to patients as a treatment option for precancerous cervical lesions in low\u2010resource settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13315","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T20:24:36Z","timestamp":1571343876000},"page":"1391-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Acceptability and safety of thermal ablation for the treatment of precancerous cervical lesions in Honduras"],"prefix":"10.1111","volume":"24","author":[{"given":"Manuel","family":"Sandoval","sequence":"first","affiliation":[{"name":"Asociaci\u00f3n Hondure\u00f1a de Planificaci\u00f3n de Familia Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Slavkovsky","sequence":"additional","affiliation":[{"name":"PATH Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Bansil","sequence":"additional","affiliation":[{"name":"PATH Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Jeronimo","sequence":"additional","affiliation":[{"name":"Consulting Damascus MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Lim","sequence":"additional","affiliation":[{"name":"PATH Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Salud de Honduras Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"de Sanjose","sequence":"additional","affiliation":[{"name":"PATH Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_6_3_1","unstructured":"ICO Information Centre on HPV and Cancer (HPV Information Centre).Honduras Human Papillomavirus and Related Cancers Fact Sheet 2016 [Website].2016(Available fromhttp:\/\/www.hpvcentre.net\/statistics\/reports\/HND_FS.pdf) [15 Jan 2019]."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp534"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70286-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.11.035"},{"key":"e_1_2_6_7_1","unstructured":"World Health Organization.WHO Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention [WHO 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