{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:02:38Z","timestamp":1790542958557,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the clinical severity of diarrhoea associated to viral co\u2010infection in children with acute gastroenteritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>About<\/jats:italic> 461 children under five years hospitalised with acute diarrhoea (266 males and 187 females) were enrolled in the study. Using stool samples, rotavirus and adenovirus infections were investigated by ELISA, and norovirus infections by nested duplex RT\u2010PCR. We assessed social, demographic, clinical and behavioural conditions that might influence the occurrence of rotavirus, adenovirus and norovirus infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mono\u2010viral infection was detected in 49% and mixed viral infection in 12% of patients. The prevalence of mixed infection was neither dependent on age nor sex. Three samples were infected with all three viruses. A significant association was found between fever (axillary temperature&gt;\u00a037.5\u00a0\u00b0C) and rotavirus\u2013norovirus dual infection (aOR (CI 95%) = 2.1 (1.14\u20133.84), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.016; aOR (CI 95%) = 0.37 (0.19\u20130.73), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004). Mixed infection was the most common during the dry season from June to October (71.4% versus 54.7%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Co\u2010infection with both rotavirus and norovirus is common in under\u2010five hospitalised children but does not contribute to the severity of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13317","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T22:39:00Z","timestamp":1571438340000},"page":"1427-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["High prevalence of norovirus and rotavirus co\u2010infection in children with acute gastroenteritis hospitalised in Brazzaville, Republic of Congo"],"prefix":"10.1111","volume":"24","author":[{"given":"Vivaldie","family":"Mikounou Louya","sequence":"first","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of Congo"},{"name":"Faculty of Sciences and Technology University Marien Ngouabi Brazzaville Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Nguekeng Tsague","sequence":"additional","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of Congo"},{"name":"Faculty of Sciences and Technology University Marien Ngouabi Brazzaville Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Ntoumi","sequence":"additional","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of Congo"},{"name":"Faculty of Sciences and Technology University Marien Ngouabi Brazzaville Republic of Congo"},{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christevy","family":"Vouvoungui","sequence":"additional","affiliation":[{"name":"Fondation Congolaise pour la Recherche M\u00e9dicale Brazzaville Republic of Congo"},{"name":"Faculty of Sciences and Technology University Marien Ngouabi Brazzaville Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Charles","family":"Kobawila","sequence":"additional","affiliation":[{"name":"Faculty of Sciences and Technology University Marien Ngouabi Brazzaville Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.08.013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.06.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23744"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70253-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.10.003"},{"key":"e_1_2_7_7_1","unstructured":"World Health Organization.Diarrhoeal disease. 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