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Three samples were prepared and stored at 5 and 25\u00a0\u00b0C and assayed at 0, 7, 14 and 30\u00a0days. Physical parameters (appearance, pH, particle size and viscosity) were also monitored. Microbiological examination was performed through the suitable counting method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The formulations presented a sulfadiazine concentration of around 95% at the beginning at both temperatures. There was some variation in pH, viscosity and particle size distribution over time. The samples met the pharmacopoeia criteria of microbiological quality over 30\u00a0days, but only sulfadiazine formulated in syrup stored at 25\u00a0\u00b0C was suitable for use after one week.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sulfadiazine suspension in simple syrup was chosen as the most suitable formulation because it demonstrated stability for 14\u00a0days at room temperature, providing an alternative liquid dosage form of sulfadiazine for congenital toxoplasmosis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13354","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T07:12:26Z","timestamp":1575529946000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Stability of extemporaneous sulfadiazine oral suspensions from commercially available tablets for treatment of congenital toxoplasmosis"],"prefix":"10.1111","volume":"25","author":[{"given":"Brunna","family":"Soares Rodrigues Costa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Norte Natal Brasil"},{"name":"N\u00facleo de Pesquisa em Alimentos e Medicamentos Universidade Federal do Rio Grande do Norte Natal Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Pontes do Nascimento","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia Universidade Federal do Rio Grande do Norte Natal Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"V\u00edtor de Paiva Amorim","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Alimentos e Medicamentos Universidade Federal do Rio Grande do Norte Natal Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Barreto Gomes","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Norte Natal Brasil"},{"name":"Departamento de Farm\u00e1cia Universidade Federal do Rio Grande do Norte Natal Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourena","family":"Mafra Ver\u00edssimo","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Alimentos e Medicamentos Universidade Federal do Rio Grande do Norte Natal Brasil"},{"name":"Departamento de Farm\u00e1cia Universidade Federal do Rio Grande do Norte Natal Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088588"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedhc.2010.04.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5070.190813"},{"key":"e_1_2_6_5_1","first-page":"364","article-title":"Congenital toxoplasmosis in a reference center of Paran\u00e1, Southern Brazil. 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