{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:13:03Z","timestamp":1768252383533,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The appetite test is used to risk stratify for children with severe acute malnutrition (SAM) in inpatient or outpatient care. The test is recommended in guidelines despite lack of evidence. We evaluated its ability to identify children at risk of a poor treatment outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted an observational study of children diagnosed with SAM at three health facilities in Ethiopia. The appetite test was done independently, and the result did not affect decisions about hospitalisation and clinical care. Data were analysed using mixed linear and logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Appetite was tested in 298 (89%) of 334 children enrolled; 56 (19%) passed. Children failing the appetite test had a 6.6% higher weight gain per day (95% CI: 2.6, 10.8) adjusted for type of treatment, oedema, duration of follow\u2010up and age than children passing the test. We found medical complications in 179 (54%) children. Medical complications were associated with blood markers of metabolic disturbance. Children with medical complications tended to have lower weight gain than those without complications (3.5%, 95% CI: \u22120.25, 7.0). Neither the appetite test nor medical complications were correlated with bacteraemia or treatment failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings question the use of the appetite test to identify children who need inpatient care. An assessment of medical complications alone could be a useful risk indicator but needs to be evaluated in other settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13360","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T01:24:05Z","timestamp":1576113845000},"page":"424-432","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Critical evaluation of the appetite test for children with severe acute malnutrition"],"prefix":"10.1111","volume":"25","author":[{"given":"Mike","family":"Zangenberg","sequence":"first","affiliation":[{"name":"Centre for Medical Parasitology Department of Immunology and Microbiology University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Microbiology Copenhagen University Hospital (Rigshospitalet) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alemseged","family":"Abdissa","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences and Pathology Jimma University Jimma Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ystein H.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Bergen Norway"},{"name":"Department of Microbiology Vestfold Hospital Trust T\u00f8nsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getnet","family":"Tesfaw","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences and Pathology Jimma University Jimma Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Briend","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"},{"name":"Center for Child Health Research University of Tampere School of Medicine Tampere University Hospital Tampere Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beza","family":"Eshetu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Faculty of Medical Sciences Jimma University Jimma Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen A. L.","family":"Kurtzhals","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology Department of Immunology and Microbiology University of Copenhagen Copenhagen Denmark"},{"name":"Department of Clinical Microbiology Copenhagen University Hospital (Rigshospitalet) Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsinuel","family":"Girma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health Faculty of Medical Sciences Jimma University Jimma Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60937-X"},{"key":"e_1_2_7_3_1","volume-title":"Management of Severe Malnutrition: A Manual for Physicians and Other Senior Health Workers","author":"World Health Organization","year":"1999"},{"key":"e_1_2_7_4_1","volume-title":"Guideline: Updates on the Management of Severe Acute Malnutrition in Infants and Children","author":"World Health Organization","year":"2013"},{"key":"e_1_2_7_5_1","volume-title":"Community\u2010based Therapeutic Care (CTC), A Field Manual","author":"Valid International"},{"key":"e_1_2_7_6_1","unstructured":"ACF International.Guidelines for the integrated management of severe acute malnutrition: In\u2010 and out\u2010patient treatment 2011. (Available from:https:\/\/www.actionagainsthunger.org\/publication\/guildines-integrated-management-severe-acute-malnutrition-and-out-patient-treatment)."},{"key":"e_1_2_7_7_1","unstructured":"Food and Nutrition Technical Assistance Project (FANTA).Generic Guidelines and Job Aids for Community\u2010Based Management of Acute Malnutrition (CMAM) 2010. (Available from:https:\/\/www.fantaproject.org\/focus-areas\/nutrition-emergencies-mam\/generic-cmam-materials)."},{"key":"e_1_2_7_8_1","unstructured":"Food and Nutrition Technical Assistance Project (FANTA).Training Guide for Community\u2010Based Management of Acute Malnutrition (CMAM) 2018 Version (including handouts) 2018. (Available from:https:\/\/www.fantaproject.org\/focus-areas\/nutrition-emergencies-mam\/cmam-training)."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-010-0103-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/52.6.1005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.1.26"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy042"},{"key":"e_1_2_7_13_1","unstructured":"Ministry of Health Federal Democratic Republic of Ethiopia.Protocol for the Management of Severe Acute Malnutrition 2007."},{"key":"e_1_2_7_14_1","volume-title":"Pocket book of hospital care for children: Guidelines for the management of common childhood illnesses","author":"World Health Organization","year":"2013"},{"key":"e_1_2_7_15_1","volume-title":"Integrated Management of Childhood Illness, Chart Booklet","author":"World Health Organization","year":"2014"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.05.022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053184"},{"key":"e_1_2_7_18_1","volume-title":"WHO Child Growth Standards: Length\/height\u2010for\u2010age, weight\u2010for\u2010age, weight\u2010for\u2010length, weight\u2010for\u2010height and body mass index\u2010for\u2010age: Methods and development","author":"WHO Multicentre Growth Reference Study Group","year":"2006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004313"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0016-x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30096-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.116.140822"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.13360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13360","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:37:55Z","timestamp":1694039875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/tmi.13360"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13360","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]},"assertion":[{"value":"2020-01-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}