{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:18:37Z","timestamp":1781306317822,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate co\u2010infection of <jats:italic>Strongyloides stercoralis<\/jats:italic> and <jats:italic>Trypanosoma cruzi<\/jats:italic> and to assess eosinophilia as a screening test for the detection of <jats:italic>S<\/jats:italic>. <jats:italic>stercoralis<\/jats:italic> infection in patients with Chagas disease (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective diagnostic validation study was performed on serum samples from primary care patients diagnosed with CD in the southern Barcelona metropolitan area. All samples with eosinophilia (<jats:italic>n<\/jats:italic>\u00a0=\u00a087) and a random sample of non\u2010eosinophilic sera (<jats:italic>n<\/jats:italic>\u00a0=\u00a0180) were selected. Diagnosis of CD was based on positive serology by means of two tests: ORTHO\u00ae <jats:italic>T. cruzi<\/jats:italic> ELISA test, and BIO\u2010FLASH\u00ae Chagas or Bioelisa CHAGAS. SCIMEDX ELISA STRONGY\u201096 was used to diagnose strongyloidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Strongyloides stercoralis<\/jats:italic> serology was positive in 15% of patients of whom 95% showed eosinophilia, vs. 21% of those with negative serology (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with differences in the mean eosinophil count (0.49 vs. 0.27\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l). Only 1.1% of patients with CD but without eosinophilia presented positive serology for <jats:italic>S. stercoralis,<\/jats:italic> whereas 44% of patients with CD and eosinophilia did (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Sensitivity and specificity values for eosinophilia were thus 95% and 79%, respectively. PPV was 42.5% and NPV, 98.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of co\u2010infection by <jats:italic>T. cruzi<\/jats:italic> and <jats:italic>S. stercoralis<\/jats:italic> is not negligible and has probably been underestimated for years in many areas, due to frequently subclinical infections. Therefore, serology seems mandatory for these patients and the use of eosinophilia as initial screening could facilitate the task, decreasing the number of analyses to be performed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13363","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T07:19:10Z","timestamp":1576567150000},"page":"467-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Infection by <i>Strongyloides stercoralis<\/i> in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care"],"prefix":"10.1111","volume":"25","author":[{"given":"E.","family":"Dopico","sequence":"first","affiliation":[{"name":"Laboratori Cl\u00ednic Territorial Metropolitana Sud Catalan Institute of Health Hospitalet de Llobregat Spain"},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Rando\u2010Matos","sequence":"additional","affiliation":[{"name":"Primary Care Center Florida Nord Catalan Institute of Health Hospitalet de Llobregat Spain"},{"name":"Fundaci\u00f3 Institut Universitari per a la Recerca a l'Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Solsona","sequence":"additional","affiliation":[{"name":"Primary Care Center Florida Nord Catalan Institute of Health Hospitalet de Llobregat Spain"},{"name":"Fundaci\u00f3 Institut Universitari per a la Recerca a l'Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Almeda","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3 Institut Universitari per a la Recerca a l'Atenci\u00f3 Prim\u00e0ria de Salut Jordi Gol i Gurina Barcelona Spain"},{"name":"Costa de Ponent Research Support Unit South Metropolitan Primary Care Area Management Catalan Institute of Health Cornell\u00e0 de Llobregat Spain"},{"name":"Autonoma University of Barcelona Bellaterra, Cerdanyola del Vall\u00e8s Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. L. N.","family":"Santos","sequence":"additional","affiliation":[{"name":"Advanced Public Health Laboratory Gon\u00e7alo Moniz Institute Oswaldo Cruz Foundation Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vinuesa","sequence":"additional","affiliation":[{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge Hospitalet de Llobregat Spain"},{"name":"Department of Pathology and Experimental Therapeutics University of Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.13.129601"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31612-4"},{"key":"e_1_2_6_4_1","unstructured":"World Health Organization.Chagas Disease (American Trypanosomiasis)[Internet]. 2018. 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