{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:33:02Z","timestamp":1694118782039},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High demand for HIV\u2010services and extensive clinical guidelines force health systems in low\u2010resource settings to dedicate resources to service delivery at the expense of other priorities. Simplifying services may reduce the burden on health systems and pre\u2010antiretroviral therapy (ART) laboratory screening is among the services under consideration for simplification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the frequencies of conditions linked to ART toxicities among 34,994 adult, ART\u2010na\u00efve patients with specimens referred to the RETRO\u2010CI laboratory in Abidjan, C\u00f4te d\u2019Ivoire between 1998 and 2017. Screening included tests for serum creatinine, alanine aminotransferase (ALT) and haemoglobin (Hb) to identify renal dysfunction (estimated glomerular filtration rate\u00a0&lt;\u00a050\u00a0mL\/min), hepatic abnormalities (ALT\u00a0&gt;\u00a05\u00d7 upper limit of normal) and severe anaemia (Hb\u00a0&lt;\u00a06.5\u00a0g\/dL), respectively. We considered screening results across four eras and identified factors associated with the conditions in question.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of renal dysfunction, hepatic abnormalities and severe anaemia were largely unchanged over time and just 8.4% of patients had any of the three conditions. Key factors associated with renal dysfunction and severe anaemia were age\u00a0&gt;\u00a050\u00a0years (adjusted odds ratio (aOR): 2.53; 95% confidence interval (CI): 2.19\u20132.92; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and CD4\u00a0&lt;\u00a0100\u00a0cells\/\u00b5l (aOR: 2.57; 95% CI: 2.30\u20132.88; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The relative infrequency of conditions linked to toxicity in C\u00f4te d\u2019Ivoire supports the notion that simplification of pre\u2010ART laboratory screening may be undertaken with limited negative impact on identification of adverse events. Targeted screening may be a feasible strategy to balance detection of conditions associated with ART toxicities with simplification of services.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13364","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T06:54:45Z","timestamp":1579589685000},"page":"408-413","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of pre\u2010ART laboratory screening to identify renal, hepatic and haematological abnormalities in C\u00f4te d'Ivoire"],"prefix":"10.1111","volume":"25","author":[{"given":"P. A.","family":"Minchella","sequence":"first","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Adj\u00e9\u2010Tour\u00e9","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Abidjan C\u00f4te d\u2019Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tehe","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Abidjan C\u00f4te d\u2019Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hedje","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Abidjan C\u00f4te d\u2019Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. R.","family":"Rottinghaus","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Natacha","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Abidjan C\u00f4te d\u2019Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Diallo","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Pretoria South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. L.","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Division of Global HIV and Tuberculosis Centers for Disease Control and Prevention Abidjan C\u00f4te d\u2019Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Nkengasong","sequence":"additional","affiliation":[{"name":"Africa Centres for Disease Control and Prevention Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"WHO.Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach.WHO:Geneva;2006."},{"key":"e_1_2_7_3_1","unstructured":"WHO.Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach.WHO:Geneva;2010."},{"key":"e_1_2_7_4_1","unstructured":"WHO.Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach.WHO:Geneva;2013."},{"key":"e_1_2_7_5_1","unstructured":"WHO.Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach 2nd edn.WHO:Geneva;2016."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.20.5.21654"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4102\/sajhivmed.v18i1.776"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4353-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.01.022"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f2306e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707233170402"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/135965350601100612","article-title":"Prevalence, incidence and predictors of severe anaemia with zidovudine\u2010containing regimens in African adults with HIV infection within the DART trial","volume":"11","author":"Ssali F","year":"2006","journal-title":"Antivir Ther"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00750.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002357"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1818"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200317003-00002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp765"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu945"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091229"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2012.01006.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-13-42"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.7.782"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31821008eb"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-018-0099-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics7040058"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.13364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13364","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13364","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:38:03Z","timestamp":1694039883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/tmi.13364"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13364","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]},"assertion":[{"value":"2020-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}