{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:28:19Z","timestamp":1775806099514,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterise the occurrence of fever (\u226538.0\u00b0C) after treatment for post\u2010partum haemorrhage (PPH) with sublingual misoprostol 800 mcg in Latin America, where elevated rates of misoprostol\u2019s thermoregulatory effects and recipients\u2019 increased susceptibility to high fever have been documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study in hospitals in Argentina enrolled consenting women with atonic PPH after vaginal delivery, eligible to receive misoprostol. Corporal temperature was assessed at 30, 60, 90 and 120\u00a0min post\u2010treatment; other effects were recorded. The incidence of high fever\u00a0\u2265\u00a040.0\u00b0C (primary outcome) was compared to the rate observed previously in Ecuador. Logistic regressions were performed to identify clinical and population\u2010based predictors of misoprostol\u2010induced fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Transient shivering and fever were experienced by 75.5% (37\/49) of treated participants and described as acceptable by three\u2010quarters of women interviewed (35\/47). The high fever rate was 12.2% (6\/49), [95% Confidence Interval (CI) 4.6, 24.8], compared to Ecuador\u2019s rate following misoprostol treatment (35.6% (58\/163) [95% CI 28.3, 43.5], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Significant predictors of misoprostol\u2010induced fever (model dependent) were as follows: pre\u2010delivery haemoglobin\u00a0&lt;\u00a011.0g\/dl, rapid placental expulsion, and higher age of the woman. No serious outcomes were reported prior to discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Misoprostol to treat PPH in Argentina resulted in a significantly lower rate of high fever than in Ecuador, although both are notably higher than rates seen elsewhere. A greater understanding of misoprostol\u2019s side effects and factors involved in their occurrence, including genetics, will help alleviate concerns. The onset of shivering may be the simplest way to know if fever can also be expected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13389","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T23:03:53Z","timestamp":1583881433000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High fever after sublingual administration of misoprostol for treatment of post\u2010partum haemorrhage: a hospital\u2010based, prospective observational study in Argentina"],"prefix":"10.1111","volume":"25","author":[{"given":"Jill","family":"Durocher","sequence":"first","affiliation":[{"name":"Gynuity Health Projects New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus Daniel","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Hospital Materno Neonatal E.T. de Vidal Corrientes Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilana G.","family":"Dzuba","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elba","family":"Mirta Morales","sequence":"additional","affiliation":[{"name":"Hospital Materno Neonatal E.T. de Vidal Corrientes Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Carroli","sequence":"additional","affiliation":[{"name":"Centro Rosarino de Estudios Perinatales Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesica","family":"Esquivel","sequence":"additional","affiliation":[{"name":"Hospital Materno Neonatal E.T. de Vidal Corrientes Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanne","family":"Martin","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Berecoechea","sequence":"additional","affiliation":[{"name":"Hospital Llano Corrientes Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beverly","family":"Winikoff","sequence":"additional","affiliation":[{"name":"Gynuity Health Projects New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_8_3_1","unstructured":"GTR: Regional Task Force for the Reduction of Maternal Mortality.Overview of the Situation of Maternal Morbidity and Mortality: Latin America and the Caribbean. December 2017."},{"key":"e_1_2_8_4_1","volume-title":"WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage","author":"World Health Organization","year":"2012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.03.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12181"},{"key":"e_1_2_8_7_1","unstructured":"FLASOG: Federaci\u00f3n Latinoamericana de Obstetricia y Ginecolog\u00eda.Uso del misoprostol en obstetrician y gynecologia. Tercer Edicio 2013."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002351"},{"key":"e_1_2_8_9_1","unstructured":"OPS: Organizaci\u00f3n Panamericana de la Salud.Gu\u00edas para la atenci\u00f3n de las principales emergencias obst\u00e9tricas2a ed. Washington D.C.: OPS; 2019."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00275-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001394"},{"key":"e_1_2_8_12_1","first-page":"QD01\u201002","article-title":"Misoprostol induced convulsion\u2010a rare side effect of misoprostol","volume":"11","author":"Sharma N","year":"2017","journal-title":"J Clin Diagn Res"},{"issue":"7","key":"e_1_2_8_13_1","first-page":"CD008982","article-title":"Postpartum misoprostol for preventing maternal mortality and morbidity","volume":"15","author":"Hofmeyr GJ","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61923-1"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61924-3"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12257"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13540"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12756"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02564.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-017-2661-2"},{"key":"e_1_2_8_21_1","first-page":"033","article-title":"A drug reaction mimics perinatal sepsis","volume":"6","author":"Tatke J","year":"2019","journal-title":"J Neonatol Clin Pediatr"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182707341"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-12-65"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.15.53"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12395"},{"key":"e_1_2_8_26_1","first-page":"15","article-title":"Morbilidad severa materna y neonatal: Vigilancia en servicios y capacidad de respuesta del sistema de salud","volume":"5","author":"Abalos E","year":"2014","journal-title":"Rev Argent Salud P\u00fablica"},{"key":"e_1_2_8_27_1","unstructured":"An\u00e1lisis de la Mortalidad Materno Infantil 2007\u20102016 a partir de la informaci\u00f3n proveniente del Sistema de Estad\u00edsticas Vitales de la Rep\u00fablica Argentina[2017] (Available from:http:\/\/www.msal.gob.ar\/images\/stories\/bes\/graficos\/0000001229cnt\u2010analisis\u2010mmi\u20102007\u20102016.pdf.)"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.08.004"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-13-46"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.31403\/rpgo.v54i1150","article-title":"Disponibilidad y uso obst\u00e9trico del misoprostol en los pa\u00edses de Am\u00e9rica Latina y el Caribe","volume":"54","author":"T\u00e1vara\u2010Orozco L","year":"2008","journal-title":"Rev Per Ginecol Obstet"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.31403\/rpgo.v59i2","article-title":"Regulacion del uso obstetrico del misoprostol en los pa\u00edses de America Latina y el Caribe","volume":"59","author":"T\u00e1vara\u2010Orozco L","year":"2013","journal-title":"Rev Per Ginecol Obstet"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1641569"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.023"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000514"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.05.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60348-0"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2008.04.002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(11)60005-2"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4265091"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10081000"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00272"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.t01-1-02019.x"},{"key":"e_1_2_8_43_1","volume-title":"Pregnancy, Childbirth, Postpartum and Newborn Care: A Guide for Essential Practice","author":"World Health Organization, United Nations Population Fund, UNICEF","year":"2015"},{"issue":"2","key":"e_1_2_8_44_1","first-page":"CD003249","article-title":"Abou El Senoun G, Shakur H, Alfirevic Z. Treatment for Primary Postpartum Hemorrhage","volume":"13","author":"Mousa HA","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-1188-1"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.13389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:02:57Z","timestamp":1693958577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/tmi.13389"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13389","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]},"assertion":[{"value":"2020-04-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}