{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T09:04:02Z","timestamp":1781600642870,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>HIV and sickle cell disease (SCD) are significant causes of morbidity and mortality in sub\u2010Saharan Africa. Given their separate roles in immune dysregulation, our objective was to characterise the impact that SCD has on the presentation and progression of paediatric HIV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was a retrospective cohort study (study period 2004\u20132018). Cases of HIV\u00a0+\u00a0and SCD\u2010afflicted patients (HIV+\/SCD+) were obtained via electronic chart review from a paediatric HIV clinic in Kampala, Uganda and matched 1:3 with HIV\u00a0+\u00a0controls without SCD (HIV+\/SCD\u2010).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five HIV+\/SCD\u00a0+\u00a0subjects and 95 HIV+\/SCD\u2010 controls were analysed (39% female (51\/130), age 3.6\u00a0years (SD3.9)). At baseline, WHO clinical stage (64% total cohort Stage III\/IV) and nutritional status (9.4% severe acute malnutrition) were similar for both groups, whereas HIV+\/SCD\u00a0+\u00a0had higher though non\u2010significant baseline CD4 count (1036 (SD713) vs 849 (SD638) cells\/microlitre, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.20, two\u2010tailed t\u2010test). There were 19 deaths, 6 (17%) HIV+\/SCD\u00a0+\u00a0and 13 (14%) HIV+\/SCD\u2010, with unadjusted\/adjusted models showing no significant difference. Nutritional progression and clinical stage progression showed no significant differences between groups. Kaplan\u2013Meier analysis showed a slower rate of treatment failures in the HIV+\/SCD\u00a0+\u00a0cohort (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.11, log\u2010rank survival test). Trajectory analysis showed that in the time period analysed, the HIV+\/SCD\u00a0+\u00a0cohort showed a more rapid rise and higher total CD4 count (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012, regression analysis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study suggests that SCD does not adversely affect the progression of HIV in patients on ART. Further, HIV+\/SCD\u00a0+\u00a0achieved higher CD4 counts and fewer HIV treatment failures, suggesting physiological effects due to SCD might mitigate HIV progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13408","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T06:49:47Z","timestamp":1587710987000},"page":"897-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of sickle cell disease on presentation and progression of paediatric HIV: a retrospective cohort study"],"prefix":"10.1111","volume":"25","author":[{"given":"Joseph","family":"Ssenyondwa","sequence":"first","affiliation":[{"name":"Baylor College of Medicine Children\u2019s Foundation Kampala Uganda"},{"name":"Texas Children\u2019s Hospital \u2013 Global HOPE Program Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"George","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Carlos Bazo\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Universidad Cat\u00f3lica Los Angeles de Chimbote Chimbote Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mercedes","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline B.","family":"Kanywa","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children\u2019s Foundation Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Naturinda","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine Children\u2019s Foundation Kampala Uganda"},{"name":"Texas Children\u2019s Hospital \u2013 Global HOPE Program Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L. M.","family":"Wasswa","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital \u2013 Global HOPE Program Kampala Uganda"},{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lubega","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Hospital \u2013 Global HOPE Program Kampala Uganda"},{"name":"Baylor College of Medicine and Texas Children\u2019s Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UNAIDS.Joint United Nations Programme on HIV\/AIDS (UNAIDS). Global and Regional data HIV\/SIDA pag. 2017;12\u201316."},{"key":"e_1_2_6_3_1","unstructured":"UNAIDSCountry Fact Sheet \u2010 Uganda[Internet]. 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