{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:42:49Z","timestamp":1694119369079},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine clinical correlates of the peripheral absolute eosinophil count (AEC) among bacteriologically confirmed TB patients in Uganda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We evaluated data of bacteriologically confirmed adult TB patients who had a peripheral blood AEC measurement at the National TB Treatment Center in Uganda during a cross\u2010sectional study. We performed linear regression analysis for correlates of log\u2010transformed AEC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 235 patients in this analysis with a median (interquartile range, IQR) age of 31 (24\u201339) years. 60.4% were male, and 33.6% had TB\/HIV co\u2010infection. In a multivariable linear regression model that controlled for age, residence type, HIV status, weight loss, anorexia, body mass index, CD8+ T\u2010cell count, haemoglobin level and TB bacillary load, males had a 47.0% higher AEC than females (adjusted coefficient (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>)\u00a0=\u00a00.385, 95% confidence interval (CI) 0.012\u20130.759 <jats:italic>P<\/jats:italic>\u00a0=\u00a00.043). Also, a 1\u00a0\u00b0C raise in temperature resulted in an 11.5% decrease in the AEC (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a0\u22120.122 95% CI (\u22120.233 to \u22120.011) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.031) while a 1\u00a0cell\/mm<jats:sup>3<\/jats:sup> increase in the CD4+ T\u2010cell count resulted in a 0.10% increase in the AEC (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.001 95% CI (0.000\u20130.001) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The AEC was higher among males than females, consistent with the normal population distribution of AEC among Ugandans. The AEC was weakly but positively correlated with the CD4 count and negatively correlated with temperature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13454","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T10:47:55Z","timestamp":1592995675000},"page":"1079-1084","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Absolute eosinophil count correlates with temperature and CD4 count independently of HIV infection among tuberculosis patients"],"prefix":"10.1111","volume":"25","author":[{"given":"Joseph Baruch","family":"Baluku","sequence":"first","affiliation":[{"name":"Pulmonology Division Mulago National Referral Hospital Kampala Uganda"},{"name":"Mildmay Uganda Kampala Uganda"},{"name":"Makerere University Lung Institute Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godwin Tukumbo","family":"Anguzu","sequence":"additional","affiliation":[{"name":"Makerere University Infectious Disease Institute Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Bongomin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Makerere University College of Health Sciences Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dathan Mirembe","family":"Byonanebye","sequence":"additional","affiliation":[{"name":"Makerere University Infectious Disease Institute Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Global tuberculosis report 2019. 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