{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:36:50Z","timestamp":1791362210068,"version":"4.3.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006507","name":"Funda\u00e7\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407060"],"award-info":[{"award-number":["407060"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["2018\u20109]"],"award-info":[{"award-number":["2018\u20109]"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the correlation between the burden of seven priority neglected tropical diseases (NTDs) included in the Brazilian National Agenda of Priorities in Health Research \u2013 tuberculosis, Chagas disease, leprosy, malaria, leishmaniasis, dengue and schistosomiasis \u2013 and their respective research funding and output.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective review obtained data on disease burden from the Global Burden of Disease Study and funding data from open access sources. Publications were retrieved from Scopus and SciELO, and characterised according to the type of research conducted. Correlation between funding, research output and burden was assessed by comparing the 'expected' and 'observed' values for funding and publications relative to the proportional burden for each disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an emphasis in basic biomedical research (average 30% of publications) and a shortage of health policy and systems (average 7%) and social sciences research (average 3%). Research output and funding were poorly correlated with disease burden. Tuberculosis, Chagas disease and schistosomiasis accounted for more than 75% of total NTD\u2010related DALYs, but accounted for only 34% of publications. Leprosy, leishmaniasis and malaria, together, received 49% of NTD\u2010related funding despite being responsible for only 9% of DALYs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The analysis evidenced a lack of correlation between disease burden, research output and government funding for priority NTDs in Brazil. Our findings highlight the importance of monitoring health needs, research investments and outputs to inform policy and optimise the uptake of evidence for action, particularly in developing countries, where resources are scarce and the research capacity is limited. The results contribute to health policy by highlighting the need for improving coordination of scientific activities and public health needs for effective impact.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13478","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T09:11:19Z","timestamp":1598692279000},"page":"1373-1384","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Neglected tropical diseases in Brazil: lack of correlation between disease burden, research funding and output"],"prefix":"10.1111","volume":"25","author":[{"given":"Bruna de Paula","family":"Fonseca","sequence":"first","affiliation":[{"name":"Center for Technological Development in Health Oswaldo Cruz Foundation Manguinhos Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Costa","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Center for Technological Development in Health Oswaldo Cruz Foundation Manguinhos Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Zicker","sequence":"additional","affiliation":[{"name":"Center for Technological Development in Health Oswaldo Cruz Foundation Manguinhos Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12961-018-0302-4","article-title":"A comparison between health research output and burden of disease in Arab countries: evidence from Palestine","volume":"16","author":"Albarqouni L","year":"2018","journal-title":"Health Res Policy Syst"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090147"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","DOI":"10.1186\/1478-4505-12-64","article-title":"Are the Norwegian health research investments in line with the disease burden?","volume":"12","author":"Kinge JM","year":"2014","journal-title":"Health Res Policy Syst"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.micinf.2014.07.006","article-title":"Brazil\u2019s neglected tropical diseases: an overview and a report card","volume":"16","author":"Hotez PJ","year":"2014","journal-title":"Microbes Infect."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60202-X"},{"key":"e_1_2_6_7_1","unstructured":"Ministry of Health.National Agenda of Priorities in Health Research \u2013 Brazil [Internet];2006. (Available from:http:\/\/bvsms.saude.gov.br\/bvs\/publicacoes\/agenda_ingles.pdf)."},{"key":"e_1_2_6_8_1","first-page":"2291","article-title":"Meanings of Neglected Diseases in the Global Health agenda: the place of populations and territories","volume":"23","author":"Oliveira RG","year":"2018","journal-title":"Ci\u00eanc Amp Sa\u00fade Coletiva"},{"key":"e_1_2_6_9_1","first-page":"200","article-title":"Neglected diseases: the strategies of the Brazilian Ministry of Health","volume":"44","author":"Ministry of Health","year":"2010","journal-title":"Rev Sa\u00fade P\u00fablica"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/507401a"},{"issue":"1","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1355819613476015","article-title":"Burden of disease, research funding and innovation in the UK: Do new health technologies reflect research inputs and need?","volume":"18","author":"Ward D","year":"2013","journal-title":"J Health Serv Res Policy"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"e0005309","DOI":"10.1371\/journal.pntd.0005309","article-title":"Will a new 2017 global leadership commit to NTDs?","volume":"11","author":"Hotez PJ","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"e0005431","DOI":"10.1371\/journal.pntd.0005431","article-title":"NTD policy priorities: Science, values, and agenda setting","volume":"11","author":"Iltis AS","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"e_1_2_6_14_1","unstructured":"Uniting to combat neglected tropical diseases.London Declaration on Neglected Tropical Diseases. Ending the neglect & reaching 2020 goals;2012. (Available from:https:\/\/unitingtocombatntds.org\/wp\u2010content\/uploads\/2017\/11\/london_declaration_on_ntds.pdf)"},{"key":"e_1_2_6_15_1","unstructured":"WHO.Ending the neglect to attain the Sustainable Development Goals: a road map for neglected tropical diseases 2021\u20132030 [Internet]. Geneva;2020. (Available from:https:\/\/www.who.int\/neglected_diseases\/Revised\u2010Draft\u2010NTD\u2010Roadmap\u201023Apr2020.pdf) [3 Aug 2020]."},{"key":"e_1_2_6_16_1","unstructured":"United Nations.Sustainable development goals \u2013United Nations [Internet]. United Nations Sustainable Development. (Available from:http:\/\/www.un.org\/sustainabledevelopment\/sustainable\u2010development\u2010goals\/) [20 Jan 2017]."},{"key":"e_1_2_6_17_1","unstructured":"GBD.Global Burden of Disease Study 2016. Results [Internet]. Institute for Health Metrics and Evaluation (IHME);2017. (Available from:http:\/\/ghdx.healthdata.org\/gbd\u2010results\u2010tool)."},{"key":"e_1_2_6_18_1","unstructured":"WHO.Metrics: Disability\u2010Adjusted Life Year (DALY) [Internet]. WHO. (Available from:http:\/\/www.who.int\/healthinfo\/global_burden_disease\/metrics_daly\/en\/) [16 Apr 2018]."},{"key":"e_1_2_6_19_1","unstructured":"Pesquisa Sa\u00fade [Internet]. (Available fromhttp:\/\/pesquisasaude.saude.gov.br\/) [10 Apr 2018]."},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1478-4505-8-25","article-title":"Overview of research activities associated with the World Health Organization: results of a survey covering 2006\/07","volume":"8","author":"Terry RF","year":"2010","journal-title":"Health Res Policy Syst"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2009.00119.x"},{"key":"e_1_2_6_22_1","unstructured":"WHO.WHO Commission on Macroeconomics and Health. Macroeconomics and Health: Investing in Health for Economic Development. Report of the Commission on Macroeconomics and Health. [Internet]. Geneva;2001. (Available from:https:\/\/apps.who.int\/iris\/handle\/10665\/42463)"},{"key":"e_1_2_6_23_1","unstructured":"Medecins Sans Frontieres.Access to Essential Medicines Campaign and the Drugs for Neglected Diseases Working Group. Fatal Imbalance: The Crisis in Research and Development for Drugs for Neglected Diseases. [Internet]. Brussels;2001. (Available from:https:\/\/www.msf.org\/fatal\u2010imbalance\u2010crisis\u2010research\u2010and\u2010development\u2010drugs\u2010neglected\u2010diseases)"},{"key":"e_1_2_6_24_1","unstructured":"WHO.Neglected tropical diseases [Internet]. World Health Organization. (Available from:http:\/\/www.who.int\/neglected_diseases\/en\/) [4 Aug 2020]."},{"key":"e_1_2_6_25_1","unstructured":"PLOS Neglected Tropical Diseases [Internet]. PLOS Neglected Tropical Diseases. (Available from:https:\/\/journals.plos.org\/plosntds\/s\/journal\u2010information) [4 Aug 2020]."},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1681394"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105906"},{"issue":"1","key":"e_1_2_6_28_1","first-page":"S35","article-title":"Brazilian Tuberculosis Research Network\u2010REDE\u2010TB","volume":"15","author":"Kritski A","year":"2016","journal-title":"Inst Hig Med Trop"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11192-006-0055-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-4505-8-32"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-4505-1-1"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-4505-2-6"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16987-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.ijcard.2013.12.095","article-title":"Alignment of United States funding for cardiovascular disease research with deaths, years of life lost, and hospitalizations","volume":"172","author":"Stockmann C","year":"2014","journal-title":"Int J Cardiol."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001696"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000030"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6512"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007111"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000237"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006469"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001312"},{"key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"e108787","DOI":"10.1371\/journal.pone.0108787","article-title":"How are health research priorities set in low and middle income countries? A systematic review of published reports","volume":"9","author":"McGregor S","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respol.2013.05.008"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3727LFE"}],"updated-by":[{"DOI":"10.1111\/tmi.13536","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T00:00:00Z","timestamp":1609632000000}}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13478","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T07:10:24Z","timestamp":1693811424000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/tmi.13478"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13478","archive":["Portico"],"relation":{"erratum":[{"id-type":"doi","id":"10.1111\/tmi.13536","asserted-by":"object"}]},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]},"assertion":[{"value":"2020-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}