{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:25:08Z","timestamp":1790699108840,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>abstarct<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterise the epidemiological patterns and the spatial\u2013temporal distribution of schistosomiasis\u2010related mortality in Brazil from 2003 to 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A national population\u2010based ecological study that used official data from the Mortality Information System. The data included all deaths recorded in Brazil from 2003 to 2018 in which schistosomiasis was mentioned in the death certificate as an underlying or associated cause of death (multiple causes). The municipalities of residence were used as units of geographic analysis, and standardised and smoothed mortality rates (per 100\u00a0000 inhabitants) were calculated using the local empirical Bayes method. Spatial autocorrelation was evaluated using global and local Moran indexes. To analyse the spatial dependence, the Getis\u2010Ord G and Gi* statistics were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 18\u00a0421\u00a0113 deaths were recorded in Brazil. Schistosomiasis was mentioned in 11\u00a0487 deaths (proportional mortality: 0.06%); for 8141 deaths (70.87%), it was listed as the underlying cause, and for 3346 deaths (29.13%), it was listed as an associated cause. The mean mortality rate was 0.38 deaths\/100\u00a0000 inhabitants. Individuals\u00a0\u2265\u00a070\u00a0years of age (RR: 115.34, 95% CI: 68.56\u2013194.03) and residents in the Northeast region (RR: 10.81, 95% CI: 5.95\u201319.66) presented higher risks related to schistosomiasis. Municipalities with high mortality rates were identified in all regions, and high\u2010risk clusters were found in municipalities located in the Northeast and Southeast regions of the country.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Schistosomiasis remains an important cause of death in persistently endemic areas in Brazil, particularly in those with a high prevalence of the disease and a marked parasite load.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13483","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:28:46Z","timestamp":1599143326000},"page":"1395-1407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Burden of schistosomiasis\u2010related mortality in Brazil: epidemiological patterns and spatial\u2013temporal distribution, 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Filho","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis Laboratory of Research in Molluscan Parasitology and Biology Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-2494","authenticated-orcid":false,"given":"Mauric\u00e9lia da Silveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis Laboratory of Research in Molluscan Parasitology and Biology Federal University of Cear\u00e1 Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3690-5023","authenticated-orcid":false,"given":"Francisco Rogerlandio","family":"Martins\u2010Melo","sequence":"additional","affiliation":[{"name":"Post\u2010Graduate Programme in Public Health School of Medicine Federal University of Cear\u00e1 Fortaleza Cear\u00e1 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