{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T12:16:44Z","timestamp":1784722604725,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Sickle cell disease is an important public health issue that is increasingly recognised as a substantial contributor to morbidity and early childhood mortality in sub\u2010Saharan Africa. We aimed to provide information from large\u2010scale, long\u2010term sickle cell screening efforts in Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used nationally representative data from the centralised public health laboratory database in Uganda to examine epidemiological trends in sickle cell screening over a five\u2010year period, comparing age and geographic adjustments to prevalence among different testing cohorts of children aged 0\u201324\u00a0months, and calculating screening coverage within high\u2010burden districts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 324\u00a0356 children aged 0\u201324\u00a0months were screened for sickle cell trait and disease from February 2014 to March 2019. A high national burden of sickle cell disease (0.9%) was confirmed among a cohort of samples co\u2010tested with HIV. In the cohort of samples referred specifically for sickle cell testing, the overall prevalence of sickle cell disease was 9.7% and particularly elevated in high\u2010burden districts where focused screening occurred. The majority of children were screened before age 4\u00a0months, but the sickle\u2010specific cohort had a larger proportion of affected children tested between age 5\u20139\u00a0months, coincident with onset of disease signs and symptoms. Successful screening coverage of sickle cell disease births was achieved in several high\u2010burden districts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Examination and analysis of national sickle cell screening trends in Uganda documents the successes of focused screening strategies as an important step towards universal screening. With this evidence and increased healthcare provider knowledge, Uganda can optimise sickle cell diagnosis and management across the country.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13506","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T16:06:12Z","timestamp":1604592372000},"page":"23-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Trends in sickle cell trait and disease screening in the Republic of Uganda, 2014\u20132019"],"prefix":"10.1111","volume":"26","author":[{"given":"Arielle G.","family":"Hernandez","sequence":"first","affiliation":[{"name":"Division of Hematology Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"},{"name":"Global Health Center Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Epidemiology Human Genetics, and Environmental Sciences University of Texas Health Science Center  Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Kiyaga","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratories Ministry of Health Republic of Uganda  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thad A.","family":"Howard","sequence":"additional","affiliation":[{"name":"Division of Hematology Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"},{"name":"Global Health Center Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Ssewanyana","sequence":"additional","affiliation":[{"name":"Central Public Health Laboratories Ministry of Health Republic of Uganda  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Ndeezi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane R.","family":"Aceng","sequence":"additional","affiliation":[{"name":"Ministry of Health Republic of Uganda  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell E.","family":"Ware","sequence":"additional","affiliation":[{"name":"Division of Hematology Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"},{"name":"Global Health Center Cincinnati Children\u2019s Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_2_7_3_1","first-page":"239","article-title":"Geographical survey of beta 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