{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:30:10Z","timestamp":1769747410388,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Intra\u2010cerebral Haemorrhage (ICH) seems more prevalent in sub\u2010Saharan Africa (SSA) than in High\u2010Income Countries (HIC) with poorer clinical outcome. Higher impact of hypertension and\/or amyloid angiopathy could account for this disproportion. Here, we sought to (i) retrospectively compare ICH clinical and imaging patterns in Belgium and Guinea and in a subsequent cohort (ii) prospectively compare brain MRI characteristics to seek evidence for a different proportion of amyloid angiopathy patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety one consecutive patients admitted for spontaneous ICH at Brussels Erasme\u2010ULB Hospital and at Conakry Ignace Deen\u2010UGANC were retrospectively compared in terms of ICH volume estimated with the ABC\/2 method, clinical characteristics and modified ranking (mRS) score at 30\u00a0days. mRS was dichotomised as good outcomes (\u22643) and poor outcomes (&gt;3). A prospective cohort of 30 consecutive patients with ICH admitted at CHU Conakry Ignace Deen\u2010UGANC was prospectively included to undergo brain MRI. Results of the Guinean MRI were compared to 30 patients randomly selected from Brussels\u2019 initial cohort. Paired Student\u2019s <jats:italic>t<\/jats:italic>\u2010test and Mann\u2013Whitney <jats:italic>u<\/jats:italic>\u2010test were used for group comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age of ICH onset was higher in Belgium (68\u00a0\u00b1\u00a017\u00a0years <jats:italic>vs<\/jats:italic>. 56\u00a0\u00b1\u00a014\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) while ICH volume and 30\u2010day mortality rate were higher in Guinea (20\u00a0ml <jats:italic>vs<\/jats:italic>. 11\u00a0ml, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and mortality 33% <jats:italic>vs<\/jats:italic>. 10 %, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). ICH burden in survivors in Conakry and Brussels showed respectively good outcomes in 56.7% and 60.4% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09) and poor outcomes in 10.3% <jats:italic>vs<\/jats:italic>. 29.6% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). MRI analysis of the prospective cohort failed to disclose significant differences regarding brain MRI characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intra\u2010cerebral Haemorrhage affected patients 15\u00a0years younger in Guinea with larger haematoma volumes and higher mortality than in Belgium. MRI findings did not show more prevalent amyloid angiopathy pathology suggesting that better primary prevention of hypertension could positively impact ICH epidemiology in Guinea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13512","type":"journal-article","created":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T08:07:56Z","timestamp":1604736476000},"page":"166-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Insights in the pathophysiology of haemorrhagic strokes in a sub\u2010Sahara African country, an epidemiological and MRI study"],"prefix":"10.1111","volume":"26","author":[{"given":"C.","family":"Damien","sequence":"first","affiliation":[{"name":"Department of Neurology CUB Hopital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Cisse","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Ignace Deen Universit\u00e9 Gamal Abdel Nasser Conakry  Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ligot","sequence":"additional","affiliation":[{"name":"Department of Neurology CUB Hopital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Toure","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Ignace Deen Universit\u00e9 Gamal Abdel Nasser Conakry  Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Konat\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Ignace Deen Universit\u00e9 Gamal Abdel Nasser Conakry  Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.D.","family":"Barry","sequence":"additional","affiliation":[{"name":"Department of Neurology CHU Ignace Deen Universit\u00e9 Gamal Abdel Nasser Conakry  Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saw","sequence":"additional","affiliation":[{"name":"Centre de Diagnostic Caisse Nationale de S\u00e9curit\u00e9 Sociale  Conakry Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Naeije","sequence":"additional","affiliation":[{"name":"Department of Neurology CUB Hopital Erasme Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441106"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30073-4"},{"key":"e_1_2_7_5_1","unstructured":"The United Nations Department of Economic and Social Affairs.World Population Prospects 2019 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