{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:35:58Z","timestamp":1792449358219,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Better understanding of glucose metabolism in patients with HIV after initiating antiretroviral therapy (ART) is important to target treatment and follow\u2010up for diabetes risk and other non\u2010communicable diseases in resource\u2010limited settings. The aim of this study was to assess the changes and predictors of glucose metabolism and blood pressure among patients with HIV on ART for 12\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010year follow\u2010up of Ethiopian patients with HIV after initiation of ART was done. Outcomes were changes in fasting plasma glucose (FPG), and 30\u2010minute (30mPG) and 2\u2010hour plasma glucose (2hPG) after oral glucose tolerance test, glycated haemoglobin (HbA1c), fasting plasma insulin (p\u2010insulin), homeostatic model assessment index for insulin resistance (HOMA\u2010IR) and blood pressure. \u00a0<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 33 years, and the majority were women. During the first 12\u00a0months, levels of all plasma glucose parameters decreased, while p\u2010insulin (10<jats:sup>B<\/jats:sup> 3.1; 95% CI2.4, 4.0), HOMA\u2010IR (10<jats:sup>B<\/jats:sup> 3.1; 95% CI2.3, 4.0) and systolic blood pressure (B 4.0; 95% CI2.5, 5.5) increased. Fat\u2010free mass at baseline predicted higher increments in p\u2010insulin, HOMA\u2010IR and blood pressure; whereas, fat mass predicted higher increment in HbA1c.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among Ethiopian patients with HIV, blood pressure and insulin increased, and all glucose parameters declined during 12\u2010month of ART. Only longer\u2010term follow\u2010up will tell us whether insulin increase is due to insulin resistance or from recovering \u03b2\u2010cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13544","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T12:13:20Z","timestamp":1610108000000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of glucose metabolism and blood pressure among Ethiopian individuals with HIV\/AIDS after one\u2010year of antiretroviral therapy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2365-3963","authenticated-orcid":false,"given":"Hiwot","family":"Amare","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Jimma University Jimma Ethiopia"},{"name":"JUCAN Research Centre Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette F.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5se B.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alemseged","family":"Abdissa","sequence":"additional","affiliation":[{"name":"JUCAN Research Centre Jimma University Jimma Ethiopia"},{"name":"Department of Laboratory Sciences Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Yilma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jimma University Jimma Ethiopia"},{"name":"JUCAN Research Centre Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsinuel","family":"Girma","sequence":"additional","affiliation":[{"name":"JUCAN Research Centre Jimma University Jimma Ethiopia"},{"name":"Department of Paediatrics and Child Health Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Faurholt\u2010Jepsen","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports University of Copenhagen Copenhagen Denmark"},{"name":"Department of Infectious Diseases Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120902889926"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09540120802241863"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e31827e8785"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230413"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0000000000000305"},{"key":"e_1_2_7_7_1","first-page":"193","article-title":"Diabetes, metabolic syndrome and dyslipidemia in people living with HIV in Africa: re\u2010emerging challenges not to be forgotten","volume":"9","author":"Husain NE","year":"2017","journal-title":"HIV\/AIDS (Auckland, N.Z.)"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-018-0927-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6916497"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1557-0843(10)80008-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2014.04.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.152"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.937"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319451"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000257"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117461"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158999"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3187"},{"key":"e_1_2_7_19_1","volume-title":"Guideline for management of opportunistic infections and antiretroviral treatment in adolescents and adults in Ethiopia, F.H.A.P.a.C. 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