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The subjects were divided as follows: those infected individuals with allergy\u2010related symptoms (A\u2010I), those with allergy\u2010related symptoms only (A\u2010NI); those only infected (NA\u2010I); and those non\u2010infected individuals without allergy\u2010related symptoms (NA\u2010NI). We used supernatants from cell culture (mitogenic stimulation) to measure cytokine and chemokine levels using cytometric bead arrays. Serum levels of anti\u2010<jats:italic>Ascaris lumbricoides<\/jats:italic> (Asc) and anti\u2010<jats:italic>Blomia tropicalis<\/jats:italic> IgE were measured using ImmunoCAP, and sCD23 was measured using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Schistosoma mansoni<\/jats:italic> infection was associated with a lower risk of allergy\u2010related symptoms. In A\u2010I, there were higher levels of TNF\u2010\u03b1, IL\u201010, IL\u20106, IFN\u2010\u03b3 and CXCL8 than in NA\u2010NI group, with TNF\u2010\u03b1 and IL\u20106 also at higher levels compared to A\u2010NI group. Levels of IL\u20106, CXCL8, total and anti\u2010Asc IgE, as well as the numbers of eosinophils<jats:styled-content>,<\/jats:styled-content> were higher in NA\u2010I than in NA\u2010NI, and the antibodies were also lower in A\u2010NI than in NA\u2010I group. In AI and NA\u2010I, there was less production of CCL2 than in NA\u2010NI. There were no differences in the levels of IL\u20102, IL\u20104, IL\u201017, CCL5, sCD23 and anti\u2010<jats:italic>Blomia<\/jats:italic> IgE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with allergy\u2010related symptoms and infected (simultaneously) had higher levels of IL\u201010; due to the infection, there was increased production of IL\u20106 and CXCL8 and less CCL2. These data may characterize deviation to Th1 or attenuation of the Th2 response in allergy sufferers in areas endemic for schistosomiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13639","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T18:57:43Z","timestamp":1623265063000},"page":"1098-1109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Schistosoma mansoni<\/i> infection is associated with decreased risk of respiratory allergy symptoms and low production of CCL2"],"prefix":"10.1111","volume":"26","author":[{"given":"Cassia Giselle","family":"de Oliveira N\u00f3brega","sequence":"first","affiliation":[{"name":"Setor de Imunologia Laborat\u00f3rio de Imunopatologia Keizo Asami Universidade Federal de Pernambuco Recife Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wheverton Ricardo Correia","family":"do 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