{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:04:48Z","timestamp":1784124288940,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["205300005"],"award-info":[{"award-number":["205300005"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Antibiotics efficacy is severely threatened due to emerging resistance worldwide, but there is a paucity of antibiotics efficacy data for the West African region in general. Therefore, this study aimed to determine the antibiotic susceptibility profile of bacterial isolated from febrile children under 5\u00a0years of age in Nanoro (Burkina Faso).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood, stool and urine samples were collected from 1099 febrile children attending peripheral health facilities and the referral hospital in Nanoro Health district. Bacterial isolates from these samples were assessed for their susceptibility against commonly used antibiotics by Kirby\u2013Bauer method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 141 bacterial isolates were recovered from 127 febrile children of which 65 from blood, 65 from stool and 11 from urine. <jats:italic>Salmonella<\/jats:italic> isolates were most frequently isolated and found to be highly resistant to ampicillin (70%; 56\/80) and trimethoprim\u2013sulphamethoxazole (65%; 52\/80). <jats:italic>Escherichia coli<\/jats:italic> isolates showed a high resistance rate to trimethoprim\u2013sulphamethoxazole (100%), ampicillin (100%), ciprofloxacin (71.4%; 10\/14), amoxicillin\u2013clavulanate (64.3%; 9\/14), ceftriaxone (64.3%; 9\/14) and gentamycin (50%; 7\/14). Moreover, half of the <jats:italic>E<\/jats:italic>. <jats:italic>coli<\/jats:italic> isolates produced \u00df\u2010lactamase suggesting multi\u2010drug resistance against \u03b2\u2010lactam as well as non\u2010\u03b2\u2010lactam antibiotics. Multi\u2010drug resistance was observed in 54.6% (59\/108) of the isolates, mainly Gram\u2010negative bacteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed high resistance rates to common antibiotics used to treat bacterial infections in Nanoro. The work prompts the need to expand antibiotic resistance surveillance studies in Burkina Faso.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13644","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T17:00:10Z","timestamp":1624986010000},"page":"1220-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antibiotic susceptibility profile of bacterial isolates from febrile children under 5 years of age in Nanoro, Burkina Faso"],"prefix":"10.1111","volume":"26","author":[{"given":"Massa dit Achille","family":"Bonko","sequence":"first","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"},{"name":"Department of Medical Microbiology Experimental Parasitology Unit Amsterdam University Medical Centers Academic Medical Center at the University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Christian","family":"Tahita","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Kiemde","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"},{"name":"Department of Medical Microbiology Experimental Parasitology Unit Amsterdam University Medical Centers Academic Medical Center at the University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palpouguini","family":"Lompo","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibidou","family":"Yougbar\u00e9","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanase M.","family":"Some","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halidou","family":"Tinto","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Science de la Sant\u00e9 \u2013 Direction r\u00e9gionale du Centre\u2010Ouest\/Unit\u00e9 de Recherche Clinique de Nanoro Nanoro Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra F.","family":"Mens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Experimental Parasitology Unit Amsterdam University Medical Centers Academic Medical Center at the University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Menting","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Experimental Parasitology Unit Amsterdam University Medical Centers Academic Medical Center at the University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk D. 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