{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:32:38Z","timestamp":1785234758548,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Over the past few decades, life expectancy in Brazil has increased from 48\u00a0years in 1950s to 76\u00a0years in 2017. The aim of this study was to investigate the impact of ageing on: (1) the frequency of hospitalisations due to bloodstream infection (BSI); (2) the incidence of hospital\u2010acquired BSI (H\u2010BSI); (3) the incidence of BSI caused by multidrug\u2010resistant (MDR) agents and (4) the mortality rate of BSI in a public hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A hospital\u2010based case\u2010cohort study was conducted between 1 December 2013 and 31 December 2015. The data were analysed using multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 500 BSI episodes were detected, among 11,102 hospitalizations. The incidence of hospitalisations resulting from BSI was significantly higher in older than younger patients (3.7\/100 vs. 2.0\/100, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). Similarly, the incidence of hospital\u2010acquired BSI was significantly higher in older patients (2.7\/100 vs. 0.9\/100, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). <jats:italic>Klebsiella pneumoniae<\/jats:italic> (15.9%), <jats:italic>Staphylococcus aureus<\/jats:italic> (14.3%), <jats:italic>Escherichia coli<\/jats:italic> (13.1%) and <jats:italic>Acinetobacter<\/jats:italic> spp. (12.1%) were the most common agents isolated. MDR agents caused 37.6% of the BSI episodes; enteric Gram\u2010negative bacilli resistant to third\u2010 or fourth\u2010generation cephalosporins (9.7%) and carbapenem\u2010resistant <jats:italic>Acinetobacter<\/jats:italic> spp. (9.2%) were the most common MDR agents. The following complications were independently associated with ageing: Charlson comorbidity index (OR\u00a0=\u00a01.16; 95% CI\u00a0=\u00a01.09\u20131.24); BSI secondary to urinary tract infection (OR\u00a0=\u00a02.14; 95% CI\u00a0=\u00a01.29\u20133.55); BSI secondary to pneumonia (OR\u00a0=\u00a01.77; 95% CI\u00a0=\u00a01.07\u20132.93) and 30\u2010day mortality following BSI (OR\u00a0=\u00a02.19; 95% CI\u00a0=\u00a01.43\u20133.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest ageing has a significant impact on hospitalisations due to BSI, H\u2010BSI incidence and mortality from BSI in older patients attending a Brazilian public hospital. Age was not significantly associated with MDR\u2010related BSI. These results indicate that age plays an important role in the increase in morbidities and mortality resulting from BSI in Brazil and that with the increased life expectancy observed over recent decades in Brazil, the burden of BSI will be expected to continue to increase. This dynamic needs to be better understood with additional studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13650","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T07:55:32Z","timestamp":1625385332000},"page":"1276-1284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The impact of ageing on the incidence and mortality rate of bloodstream infection: A hospital\u2010based case\u2013cohort study in a tertiary public hospital of Brazil"],"prefix":"10.1111","volume":"26","author":[{"given":"Natalia C. 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