{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:18:33Z","timestamp":1784078313465,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Neurocysticercosis (NCC) and human immunodeficiency virus (HIV) have a high disease burden and are prevalent in overlapping low\u2010 and middle\u2010income areas. Yet, treatment guidance for people living with HIV\/AIDS (PLWH\/A) co\u2010infected with NCC is currently lacking. This study aims to scope the available literature on HIV\/AIDS and NCC co\u2010infection, focusing on epidemiology, clinical characteristics, diagnostics and treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The scoping literature review methodological framework, and the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses guidelines were followed. A total of 16,969 records identified through database searching, and 45 additional records from other sources were reduced to 52 included studies after a standardised selection process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two experimental studies, ten observational studies, 23 case series\/case reports and 17 reviews or letters were identified. Observational studies demonstrated similar NCC seroprevalence in PLWH\/A and their HIV\u2010negative counterparts. Of 29 PLWH\/A and NCC co\u2010infection, 17 (59%) suffered from epileptic seizures, 15 (52%) from headaches and 15 (52%) had focal neurological deficits. Eighteen (62%) had viable vesicular cysts, and six (21%) had calcified cysts. Fifteen (52%) were treated with albendazole, of which 11 (73%) responded well to treatment. Five individuals potentially demonstrated an immune\u2010reconstitution inflammatory syndrome after commencing antiretroviral therapy, although this was in the absence of immunological and neuroimaging confirmation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a paucity of evidence to guide treatment of PLWH\/A and NCC co\u2010infection. There is a pressing need for high\u2010quality studies in this patient group to appropriately inform diagnostic and management guidelines for HIV\u2010positive patients with NCC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13652","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T19:15:20Z","timestamp":1625598920000},"page":"1140-1152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neurocysticercosis and HIV\/AIDS co\u2010infection: A scoping review"],"prefix":"10.1111","volume":"26","author":[{"given":"Paul D.","family":"Jewell","sequence":"first","affiliation":[{"name":"Department of Infectious Disease Epidemiology London Centre for Neglected Tropical Disease Research Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Global Health School of Medicine Technical University of Munich Munich Germany"},{"name":"Department of Community Medicine and Global Health Centre for Global Health Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Global Health School of Medicine Technical University of Munich Munich Germany"},{"name":"Department of Community Medicine and Global Health Centre for Global Health Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Buell","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London Centre for Neglected Tropical Disease Research Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Center for Global Health Universidad Peruana Cayetano Heredia Lima Peru"},{"name":"Cysticercosis Unit Instituto Nacional de Ciencias Neurol\u00f3gicas Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Center for Global Health Universidad Peruana Cayetano Heredia Lima Peru"},{"name":"Cysticercosis Unit Instituto Nacional de Ciencias Neurol\u00f3gicas Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London Centre for Neglected Tropical Disease Research Imperial College London London UK"},{"name":"Department of Infectious Disease Epidemiology MRC Centre for Global Infectious Disease Analysis Imperial College London London UK"},{"name":"Schistosomiasis Control Initiative Foundation London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London Centre for Neglected Tropical Disease Research Imperial College London London UK"},{"name":"Department of Pathobiology and Population Sciences London Centre for Neglected Tropical Disease Research Royal Veterinary College Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Ngowi","sequence":"additional","affiliation":[{"name":"Muhimbili Medical Research Centre National Institute for Medical Research Dar es Salaam Tanzania"},{"name":"College of Health and Allied Sciences University of Dar es Salaam Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London Centre for Neglected Tropical Disease Research Imperial College London London UK"},{"name":"Department of Infectious Disease Epidemiology MRC Centre for Global Infectious Disease Analysis Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Global Health School of Medicine Technical University of Munich Munich Germany"},{"name":"Department of Community Medicine and Global Health Centre for Global Health Institute of Health and Society University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70094-8"},{"key":"e_1_2_8_3_1","unstructured":"WinklerAS&RichterH.Landscape analysis: management of neurocysticercosis with an emphasis on low\u2010 and middle\u2010income countries. 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