{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T13:44:42Z","timestamp":1780494282198,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M673259"],"award-info":[{"award-number":["2020M673259"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Tuberculous pleurisy (TP) is a common disease of extrapulmonary tuberculosis, but its diagnosis is challenging. Recently, studies have found that the pleural fluid interferon gamma release assay (PF\u2010IGRA) has important diagnostic value in TP, but the sample size of these studies was small, and the conclusions were inconsistent. Therefore, this study evaluated the diagnostic value of PF\u2010IGRA in TP through a meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a literature search in multiple databases to identify studies and calculated the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curve and area under the curve (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 26 publications, including 30 case\u2013control studies, were eventually included in the meta\u2010analysis. The results showed that the pooled sensitivity, specificity, PLR, NLR, DOR and AUC with their 95% confidence intervals were 0.90 (0.88\u20130.91), 0.87 (0.85\u20130.89), 7.64 (4.46\u201313.07), 0.13 (0.09\u20130.19), 65.45 (32.13\u2013133.33) and 0.9508, respectively. The subgroup analysis suggested that the sensitivity, specificity and AUC of PF\u2010IGRA for TP in areas with a high tuberculosis burden were significantly higher than those in areas with a low tuberculosis burden. The sensitivity and AUC of the enzyme\u2010linked immunosorbent assay method were higher than those of the enzyme\u2010linked immunosorbent assay method for IGRA, but the specificity was similar. More importantly, PF\u2010IGRA combined with adenosine deaminase (ADA) could increase the diagnostic value of TP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current meta\u2010analysis indicated that PF\u2010IGRA has high diagnostic value in diagnosing TP, especially in areas with a high TB burden. We recommended that the combination of PF\u2010IGRA and ADA is the best way to diagnose TP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13659","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T19:10:45Z","timestamp":1627067445000},"page":"1356-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The value of single or combined use of pleural fluid interferon gamma release assay in the diagnosis of tuberculous pleurisy"],"prefix":"10.1111","volume":"26","author":[{"given":"Xiang","family":"Tong","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Critical Care Medicine West China Hospital\/West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Health Management Center West China Hospital\/West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Clinical Medicine of Eight\u2010year Program West China Hospital\/West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Critical Care Medicine West China Hospital\/West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Critical Care Medicine West China Hospital\/West China School of Medicine Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization.Global tuberculosis report 2020: executive summary.2020."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e328339cf6e"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0237753"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112213"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01443"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2019.09.110"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2273"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00034-13"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.951"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01941.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.08.007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3654-z"},{"issue":"2","key":"e_1_2_6_15_1","first-page":"1871","article-title":"Diagnostic value of T\u2010Spot TB combined with INF\u2010\u03b3 and IL\u201027 in tuberculous pleurisy","volume":"15","author":"Zhang M","year":"2018","journal-title":"Exp Ther Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008412"},{"issue":"1","key":"e_1_2_6_17_1","first-page":"41","article-title":"Use of pleural fluid interferon\u2010gamma enzyme\u2010linked immunospot assay in the diagnosis of pleural tuberculosis","volume":"48","author":"Adilistya T","year":"2016","journal-title":"Acta Med Indones"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0085030"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/426139"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/523591"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00067307"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-8-35"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00005309"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02655.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.05.009"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323184"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.102181"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2012.73.3.143"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00680-13"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-695X.12006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083857"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201102400118"},{"issue":"11","key":"e_1_2_6_33_1","first-page":"99","article-title":"Clinical role of Xpert MTB\/RIF combined with T\u2010SPOT.TB in diagnosis of tuberculous pleurisy and evaluation of drug resistance","volume":"28","author":"Sun H","year":"2018","journal-title":"Chin J Mod Med (In Chinese)"},{"key":"e_1_2_6_34_1","article-title":"Comparison of interferon\u2010gamma release assays and adenosine deaminase of pleural fluid for the diagnosis of pleural tuberculosis","author":"Liu F","year":"2014","journal-title":"Chin J Tuberc Respir Dis (In Chinese)"},{"issue":"004","key":"e_1_2_6_35_1","first-page":"1422","article-title":"The detection value of three different methods in identifying the tuberculous and malignant pleural effusion","volume":"036","author":"An L","year":"2017","journal-title":"Genom Appl Biol (In Chinese)"},{"issue":"01","key":"e_1_2_6_36_1","first-page":"56","article-title":"Diagnostic value of interferon\u2010\u03b3 release assay of peripheral blood and pleural effusion for tuberculous pleurisy","volume":"43","author":"Zhou M","year":"2018","journal-title":"Med J Chin PLA (In Chinese)"},{"key":"e_1_2_6_37_1","first-page":"415","article-title":"Diagnostic value of T\u2010cell enzyme\u2010linked immunosorbent spot assay in pleural effusion and peripheral blood from patients with tuberculous pleurisy","volume":"34","author":"Wang D","year":"2016","journal-title":"Chin J Infect Dis (In Chinese)"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmyco.2012.09.005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00823-15"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2020.101941"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213728"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188631"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2009.05.012"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(03)00177-X"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:11:10Z","timestamp":1692835870000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/tmi.13659"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13659","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"2021-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}