{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:49:11Z","timestamp":1776091751576,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Human toxocariasis is a widespread zoonosis for which a chemotherapy decision and therapy effectiveness are difficult to determine. We aimed to investigate the kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis in Vietnam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The prospective study was conducted between October 2017 and June 2019. The diagnosis of toxocariasis was established based on clinical, laboratory (eosinophilia, raised IgE concentration) and serological (positive <jats:italic>Toxocara<\/jats:italic> IgG ELISA) evaluation as well as the exclusion of another helminthic co\u2010infection. The patients were followed up after seven days, then one, three and six months after chemotherapy by thiabendazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study involved 80 patients with a mean age of 41.6\u00a0\u00b1\u00a015.2\u00a0years of whom 58.8% were female. At three and six months after chemotherapy, most patients demonstrated resolution of clinical signs and symptoms, eosinophil count and IgE concentration but not in the proportion of IgG seropositivity. Skin lesions and eosinophilia resolved earlier than the other symptoms (one month after treatment). About four\u2010fifths of the patients were \u201ccured\u201d after three and six months of follow\u2010up; 33.8% showed side effects to thiabendazole therapy but no severe events were reported. The most common adverse reaction was neurologic symptoms followed by gastrointestinal or skin manifestations which lasted as long as 4\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In toxocariasis patients, cutaneous manifestations and eosinophilia resolve more rapidly than other clinical and laboratory findings while IgG titre has a very slow kinetic after therapy. Thiabendazole seems to be a potential alternative for the treatment of human toxocariasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13665","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T19:39:25Z","timestamp":1628537965000},"page":"1419-1426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The kinetic profile of clinical and laboratory findings and treatment outcome of patients with toxocariasis"],"prefix":"10.1111","volume":"26","author":[{"given":"Le Dinh Vinh","family":"Phuc","sequence":"first","affiliation":[{"name":"Medic Medical Center Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tang Xuan","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Nghe An Obstetrics and Pediatrics Hospital Vinh Nghe An Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cao Ba","family":"Loi","sequence":"additional","affiliation":[{"name":"Scientific and Training Management Department National Institute of Malaria, Parasitology and Entomology of Vietnam Ha Noi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huynh Hong","family":"Quang","sequence":"additional","affiliation":[{"name":"Institute of Malariology, Parasitology and Entomology Binh Dinh Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Duc","family":"Vinh","sequence":"additional","affiliation":[{"name":"Medical Parasitology Unit Hospital for Tropical Diseases Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4919-1739","authenticated-orcid":false,"given":"Tran\u2010Anh","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Parasitology Vietnam Military Medical University Ha Noi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.07.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30331-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.08.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-8206.2003.00172.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.07.002"},{"issue":"5","key":"e_1_2_7_7_1","first-page":"351","article-title":"[Clinical analysis of eight patients with pulmonary toxocariasis]","volume":"48","author":"Yoshikawa M","year":"2010","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.02000.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X01000464"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2770"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-4801-3.00042-4"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1989.11812374"},{"issue":"6","key":"e_1_2_7_13_1","first-page":"541","article-title":"Efficacit\u00e9 compar\u00e9e du thiabendazole et du m\u00e9bendazole dans le traitement de la toxocarose [Comparative efficacy of thiabendazole and mebendazole in the treatment of toxocariasis] [Article in French]","volume":"42","author":"Magnaval J","year":"1987","journal-title":"Therapie"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2772-y"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288702600902"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X0001230X"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.20126"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2015.05.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012361"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1780-2"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmm.IJMM_18_259"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000065240"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114618"},{"key":"e_1_2_7_24_1","first-page":"240","article-title":"Urticaire chronique et Toxocara canis. 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