{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:13:52Z","timestamp":1781849632025,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the impact of hookworm infection and preventive chemotherapy on haemoglobin levels in non\u2010pregnant populations in endemic areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Systematic review and meta\u2010analysis searching PubMed and Web of Science for articles published since 2010 reporting either hookworm prevalence and Hb concentration (cross\u2010sectional studies) or Hb concentration before and after the implementation of preventive chemotherapy (before\u2013after studies and randomised controlled trials [RCTs]). For papers published before 2010, data were extracted from a previously published systematic review. Random effects meta\u2010analyses were conducted to examine the relationship between Hb concentration and hookworm infection intensity (from cross\u2010sectional studies) and the effect of preventive chemotherapy on Hb concentration (from before\u2013after studies and RCTs). Sensitivity analyses investigated the impact of malaria endemicity and combined interventions for schistosomiasis and nutrition status on Hb concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among cross\u2010sectional studies, both light\u2010 and heavy\u2010intensity hookworm infections were associated with lower Hb in school\u2010aged children. School\u2010aged children with heavy hookworm infection in settings of high malaria endemicity had lower mean Hb than those in settings of low malaria endemicity. In non\u2010pregnant populations, deworming with albendazole was associated with an increase in Hb of 3.02\u00a0g\/L (95% CI 0.1, 6.0\u00a0g\/L). No additional benefit was seen with deworming using albendazole co\u2010administered with praziquantel for schistosomiasis infection or iron supplementation for nutrition status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm the benefits of preventive chemotherapy as a public health intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13681","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T23:26:21Z","timestamp":1632957981000},"page":"1568-1592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of hookworm infection and preventive chemotherapy on haemoglobin in non\u2010pregnant populations"],"prefix":"10.1111","volume":"26","author":[{"given":"Aisling","family":"Byrne","sequence":"first","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Manalo","sequence":"additional","affiliation":[{"name":"School of Public Health University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi E.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Vaz Nery","sequence":"additional","affiliation":[{"name":"Kirby Institute University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2013.07.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(04)58004-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.88"},{"key":"e_1_2_6_7_1","first-page":"219","article-title":"L'anemia dei contadini, fornaciai o minatori in rapporto coll'attuale epidemia negli operai del Gottardo","volume":"28","author":"Perroncito E","year":"1880","journal-title":"Ann Accad Agric Torino"},{"key":"e_1_2_6_8_1","first-page":"1","article-title":"Hookworm infection and anaemia. 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