{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:11:56Z","timestamp":1767651116488,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WI 3427\/1\u20101"],"award-info":[{"award-number":["WI 3427\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Neurocysticercosis (NCC), caused by the pork tapeworm <jats:italic>Taenia solium<\/jats:italic>, is a major cause of acquired epilepsy in endemic regions. The Republic of Uganda, one of the great\u2010lakes nations in East Africa, has undergone major strives of political instability in the past century, impeding control of <jats:italic>T<\/jats:italic>.\u00a0<jats:italic>solium<\/jats:italic> and other foodborne diseases. Building on data on the epidemiology of NCC, we aimed to assess the health and economic impact of NCC\u2010associated epilepsy and headache in Uganda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used DisMod II to generate an internally consistent, complete and age\u2010stratified set of epidemiological parameters for NCC epilepsy, and subsequently modelled the NCC headache incidence from the NCC epilepsy incidence. The health impact of both conditions was quantified in terms of Disability\u2010Adjusted Life Years (DALYs), while the economic impact was quantified as the cost of illness associated with direct healthcare costs, patient costs and productivity losses. For both assessments, we adopted an incidence perspective and used 2010 as reference year. Uncertainty was propagated using 100,000\u00a0Monte Carlo simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2010, NCC was estimated to cause more than 9000 (CI: 7685\u201311,071) new cases of epilepsy and nearly 1500 new cases of headache, eventually leading to nearly 3000 deaths. Overall, it was estimated that NCC led to more than 170,000 DALYs (5.2 per 1000 person years; 16 per incident case) and an economic loss of more than USD 75\u00a0million (8000 per incident case). Non\u2010fatal health outcomes were the largest contributors to the overall health impact, while productivity losses dominated the NCC cost of illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NCC imposes a substantial burden on public health and the economy in Uganda with poor attention given to this public health problem. Increased awareness among governments, international agencies, and general public, as well as targeted intervention studies using a One Health approach are needed to reduce the significant burden of NCC in Uganda.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13703","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T17:31:44Z","timestamp":1638552704000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Human health and economic impact of neurocysticercosis in Uganda"],"prefix":"10.1111","volume":"27","author":[{"given":"Fabian","family":"Dupont","sequence":"first","affiliation":[{"name":"Zentrum Allgemeinmedizin Saarland University  Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-6750","authenticated-orcid":false,"given":"Chiara","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Institute of Tropical Medicine  Antwerp Belgium"},{"name":"Department of Translational Physiology, Infectiology, and Public Health Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Moriku Kaducu","sequence":"additional","affiliation":[{"name":"Ministry of Health: Hon. State Minister of Health Primary Care  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Ovuga","sequence":"additional","affiliation":[{"name":"International Institute of Medicine and Science  Jinja Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6108-2586","authenticated-orcid":false,"given":"Veronika","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Global Health Faculty of Medicine Technical University of Munich  Munich Germany"},{"name":"Centre for Global Health Institute of Health and Society Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3131-6983","authenticated-orcid":false,"given":"Andrea S.","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Neurology Center for Global Health Faculty of Medicine Technical University of Munich  Munich Germany"},{"name":"Centre for Global Health Institute of Health and Society Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-6892","authenticated-orcid":false,"given":"Brecht","family":"Devleesschauwer","sequence":"additional","affiliation":[{"name":"Department of Translational Physiology, Infectiology, and Public Health Faculty of Veterinary Medicine Ghent University  Ghent Belgium"},{"name":"Department of Epidemiology and Public Health Sciensano  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01336-8"},{"key":"e_1_2_7_3_1","unstructured":"MurrellKD DornyP FlisserA NashT PawlowskiZ.WHO\/FAO\/OIE Guidelines for the surveillance prevention and control of taeniosis\/cysticercosis editor: associate editors.2005."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001920"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001923"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3030-z"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2015.12.021"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000406"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.01.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001521"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-014-0239-y"},{"key":"e_1_2_7_12_1","unstructured":"United Nations.United Nations database: population by country.2015."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7954-1-4"},{"volume-title":"Risk Factors and Socio\u2010Economic Burden of Neurocysticerocis in Uganda [Internet]","year":"2018","author":"Dupont F","key":"e_1_2_7_14_1"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129097"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001152"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61899-6"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00069-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199007000-00012"},{"volume-title":"A language and environment for statistical computing","year":"2020","author":"R Core Team","key":"e_1_2_7_20_1"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00052-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/375493"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.2.389"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01627.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.01.016"}],"container-title":["Tropical Medicine &amp; 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