{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:20:22Z","timestamp":1787239222598,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      infections are a relatively rare but potentially deadly disease found in returning travellers. We compare the national treatment guidelines of non\u2010endemic countries with the WHO guidelines for the treatment of\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Review. We identified non\u2010endemic countries with an incidence rate of imported malaria of at least one per 100,000 population and at least 50 cases annually. Using PubMed and Google Search, we reviewed national guidelines published before 1 March 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen guidelines were identified. For uncomplicated falciparum malaria, 11 of 13 countries (85%) recommend an artemisinin\u2010based combination therapy as first\u2010line regimen in adults, of which artemether\u2013lumefantrine was the most common. For severe malaria, all guidelines recommend the use of intravenous artesunate. Only three countries adjust treatment recommendations based on expected artemisinin resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment guidelines for uncomplicated falciparum malaria in non\u2010endemic countries generally adhere to WHO recommendations but often fail to mention the risk of drug resistance in returning travellers. Artemisinin\u2010based Combination Therapies (ACTs) should be the first choice for all uncomplicated malaria cases. Furthermore, the choice between ACTs should be based on regional resistance patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.13715","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T11:57:41Z","timestamp":1641211061000},"page":"129-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Are national treatment guidelines for falciparum malaria in line with WHO recommendations and is antimalarial resistance taken into consideration? \u2013 A review of guidelines in non\u2010endemic countries"],"prefix":"10.1111","volume":"27","author":[{"given":"Marc T.","family":"Visser","sequence":"first","affiliation":[{"name":"Amsterdam University Medical Centers University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rens","family":"Zonneveld","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infection Prevention Amsterdam University Medical Centers University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Peto","sequence":"additional","affiliation":[{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"},{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"van Vugt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Infectious Diseases Amsterdam University Medical Centers University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen M.","family":"Dondorp","sequence":"additional","affiliation":[{"name":"Mahidol\u2010Oxford Tropical Medicine Research Unit Faculty of Tropical Medicine Mahidol University  Bangkok Thailand"},{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob W.","family":"van der Pluijm","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Infectious Diseases Amsterdam University Medical Centers University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"WHO Guidelines for malaria","author":"WHO","year":"2021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4842-z"},{"key":"e_1_2_7_4_1","volume-title":"Malaria \u2010 Annual Epidemiological Report for 2018","year":"2020"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67176-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61924-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-019-2716-z"},{"key":"e_1_2_7_8_1","volume-title":"Artemisinin resistance and artemisinin\u2010based combination therapy efficacy","author":"WHO","year":"2019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30391-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw388"},{"key":"e_1_2_7_11_1","first-page":"w14510","article-title":"Malaria cases in Switzerland from 2005 to 2015 and recent rise of imported Plasmodium vivax malaria","volume":"147","author":"Eperon G","year":"2017","journal-title":"Swiss Med Wkly"},{"key":"e_1_2_7_12_1","unstructured":"Surveillance of malaria: Canadian Malaria Network; 2016. [cited 2021 Jan 3]. Available from:https:\/\/www.canada.ca\/en\/public\u2010health\/services\/diseases\/malaria\/surveillance\u2010malaria.html"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7002a1"},{"key":"e_1_2_7_14_1","unstructured":"Malaria fact sheet: New South Wales Government Health. 2016. [cited 2020 Dec 28]. Available from:https:\/\/www.health.nsw.gov.au\/Infectious\/factsheets\/Pages\/malaria.aspx"},{"key":"e_1_2_7_15_1","unstructured":"Malaria.Therapeutic Guidelines;2019."},{"key":"e_1_2_7_16_1","unstructured":"Richtlijn Infectieziekten Vlaanderen \u2010 Malaria.Agentschap Zorg & Gezondheid;2016."},{"key":"e_1_2_7_17_1","unstructured":"Chapter 7 \u2010 Treatment of malaria: Canadian recommendations for the prevention and treatment of malaria: Committee to Advise on Tropical Medicine and Travel; 2020. [cited 2021 Mar 1]. 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