{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:18:23Z","timestamp":1788412703020,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the urological outcomes in children with congenital Zika syndrome (CZS) and investigate the relationship between clinical and urological findings in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross\u2010sectional study involved children with CZS followed up by a referral centre for children with microcephaly in the state of Paraiba in northeast Brazil. The urological evaluation included clinical history, urine culture results, ultrasonography of the urinary tract, and urodynamic evaluation, following the protocol proposed by Costa Monteiro et al. (2017). Descriptive statistical analysis was performed in addition to association and correlation tests, considering clinical and urodynamic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 88 children with CZS (35.5\u2009\u00b1\u20095.5\u00a0months), 97.7% had microcephaly, and 51% presented urinary tract infection (UTI) confirmed with clinical history and lab tests. The number of confirmed UTI episodes varied from one to 14 per child. The urodynamic evaluation confirmed the presence of an overactive bladder in 78 children and incomplete voiding in 50. Urodynamic findings were associated with the number of confirmed UTI episodes, child's sex, and actual weight, in addition to the use of anticonvulsant and myorelaxant drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>UTIs were confirmed in most children. Other urological outcomes observed were overactive bladder and low bladder capacity, which were associated with the number of confirmed UTI episodes, use of anticonvulsants and myorelaxants, and the child's sex and weight. These are treatable conditions, and it is paramount that paediatricians, neonatologists, and infectious disease specialists are aware of them to make clinical decisions and help reduce the risk of renal damage and other morbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.13754","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:25:53Z","timestamp":1650414353000},"page":"583-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil"],"prefix":"10.1111","volume":"27","author":[{"given":"Rayssa Vieira Brand\u00e3o","family":"Ferreira","sequence":"first","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Cavalcante Guedes","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"de Oliveira Melo","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Lopes","family":"Gama","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"},{"name":"UNIFACISA  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Maria Costa","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira (FIOCRUZ)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Marin","family":"Fontes","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira (FIOCRUZ)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaura Nisya","family":"de Oliveira Cruz","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira (FIOCRUZ)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace Ferreira","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira (FIOCRUZ)  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melania Maria Ramos","family":"Amorim","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Melo","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)  Campina Grande Para\u00edba Brazil"},{"name":"UNIFACISA  Campina Grande Para\u00edba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12607"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016161584"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.3720"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0051"},{"key":"e_1_2_7_6_1","unstructured":"Brasil MDS.Boletim Epidemiol\u00f3gico. Monitoramento integrado de altera\u00e7\u00f5es no crescimento e desenvolvimento relacionadas \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika e outras etiologias infecciosas at\u00e9 a Semana Epidemiol\u00f3gica 30 de 2018. [Brazil Ministry of Health. Integrated monitoring of growth and developmental changes related to Zika virus infection and other infectious etiologies by Epidemiological Week 30 of 2018.] Brazil Ministry of Health.http:\/\/portalarquivos2.saude.gov.br\/images\/pdf\/2018\/setembro\/11\/2018-047.pdf"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-017-3634-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552011005000030"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30041-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.699115"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13081671"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2401"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2019.04.018"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193514"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2020.10.011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2021.06.033"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.056"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322011000200002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2016.11.010"},{"key":"e_1_2_7_20_1","unstructured":"Center for Diseasse Control and Prevention.Congenital Zika syndrome & other birth defects. Zika and Pregnancy.https:\/\/www.cdc.gov\/pregnancy\/zika\/testing-follow-up\/zika-syndrome-birth-defects.html"},{"key":"e_1_2_7_21_1","unstructured":"Center for Diseasse Control and Prevention.Understanding Zika virus test results. Zika Virus.https:\/\/www.cdc.gov\/zika\/hc-providers\/testing-for-zika-virus.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fzika%2Fhc-providers%2Ftestresults.html"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-2038D"},{"key":"e_1_2_7_23_1","unstructured":"Brasil Minist\u00e9rio do Trabalho e Previd\u00eancia.Norma Regulamentadora n.\u00b0 32 (Seguran\u00e7a e Sa\u00fade no Trabalho em Estabelecimentos de Sa\u00fade). Di\u00e1rio Oficial da Uni\u00e3o.https:\/\/enit.trabalho.gov.br\/portal\/images\/Arquivos_SST\/SST_Legislacao\/SST_Legislacao_Portarias_2005\/Portaria-n.-485-Aprova-NR-32.pdf"},{"key":"e_1_2_7_24_1","unstructured":"WHO.Anthro for personal computers version 3.2.2 2011: Software for assessing growth and development of the world's children. WHO.https:\/\/www.who.int\/toolkits\/child-growth-standards\/software"},{"key":"e_1_2_7_25_1","unstructured":"WHO.Screening assessment and management of neonates and infants with complications associated with Zika virus exposure in utero Rapid Advice Guideline.https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/204475\/WHO_ZIKV_MOC_16.3_eng.pdf;jsessionid=C870DD37A09252368149E2B2A221D889?sequence=1"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181af1d41"},{"key":"e_1_2_7_27_1","unstructured":"PalisanoR RosenbaumP BartlettD M.Livingston.GMFCS \u2013 E & R Gross Motor Function Classification System Expanded and Revised.https:\/\/www.canchild.ca\/system\/tenon\/assets\/attachments\/000\/000\/058\/original\/GMFCS-ER_English.pdf;2020."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.02.2692"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-021-05303-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.3.563"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.03.062"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22982"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287214528745"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20714"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2001.tb00724.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/17518423.2020.1866706"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-006-0087-x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(02)80338-X"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2735"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2010.04.005"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.04.081"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5125"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1597"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:10:58Z","timestamp":1692817858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,30]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/tmi.13754"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13754","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,30]]},"assertion":[{"value":"2022-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}