{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:27:32Z","timestamp":1792848452129,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Given that women of reproductive age in dengue\u2010endemic areas are at risk of infection, it is necessary to determine whether dengue virus (DENV) infection during pregnancy is associated with adverse outcomes. The aim of this systematic review and meta\u2010analysis is to investigate the consequences of DENV infection in pregnancy on various maternal and foetal\u2010neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic literature search was undertaken using PubMed, Google Scholar, and Embase till December 2021. Mantel\u2013Haenszel risk ratios were calculated to report overall effect size using random effect models. The pooled prevalence was computed using the random effect model. All statistical analyses were performed on MedCalc Software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>We obtained data from 36 studies involving 39,632 DENV\u2010infected pregnant women. DENV infection in pregnancy was associated with an increased risk of maternal mortality (OR\u00a0=\u00a04.14 [95% CI, 1.17\u201314.73]), stillbirth (OR\u00a0=\u00a02.71 [95% CI, 1.44\u20135.10]), and neonatal deaths (OR\u00a0=\u00a03.03 [95% CI, 1.17\u20137.83]) compared with pregnant women without DENV infection. There was no significant statistical association established between maternal DENV infection and the outcomes of preterm birth, maternal bleeding, low birth weight in neonates, and risk of miscarriage. Pooled prevalences were 14.9% for dengue shock syndrome, 14% for preterm birth, 13.8% for maternal bleeding, 10.1% for low birth weight, 6% for miscarriages, and 5.6% for stillbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DENV infection in pregnant women may be associated with adverse outcomes such as maternal mortality, stillbirth, and neonatal mortality. Hence, pregnant women should be considered an at\u2010risk population for dengue management programmes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.13783","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T07:08:37Z","timestamp":1654931317000},"page":"619-629","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Maternal and foetal\u2010neonatal outcomes of dengue virus infection during pregnancy"],"prefix":"10.1111","volume":"27","author":[{"given":"Sawai Singh","family":"Rathore","sequence":"first","affiliation":[{"name":"Internal Medicine Dr. Sampurnanand Medical College  Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharvi","family":"Oberoi","sequence":"additional","affiliation":[{"name":"Internal Medicine Dr. D. Y. 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