{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:25:12Z","timestamp":1792297512552,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the prediction ability of vascular injury biomarkers for haemodialysis requirement in patients with severe leptospirosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective study with severe leptospirosis patients hospitalised in Fortaleza, Brazil. Blood samples were collected hospital admission to quantify vascular injury biomarkers: syndecan\u20101, ICAM\u20101, VCAM\u20101, angiopoietin\u20102 and FGF\u201023. Two groups were evaluated according to haemodialysis requirement during hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients were included, with a mean age of 39\u2009\u00b1\u200918\u2009years. 88.9% were males. 53.8% needed haemodialysis and presented higher levels on hospital admission of syndecan\u20101 (572 [300\u2013811] vs. 263 [106\u2013421] ng\/ml; <jats:italic>p<\/jats:italic>\u00a0=\u20090.03), angiopoietin\u20102 (1.52 [0.72\u20132.72] vs. 0.63 [0.4\u20131.38] ng\/ml; <jats:italic>p<\/jats:italic>\u00a0=\u20090.01), and FGF\u201023 (291 [56\u20132031] vs. 10 [10\u2013806] pg\/ml; <jats:italic>p<\/jats:italic>\u00a0=\u20090.021). Syndecan\u20101 showed significant correlation with creatinine (<jats:italic>r<\/jats:italic>\u00a0=\u20090.546; <jats:italic>p<\/jats:italic>\u00a0=\u20090.05) and total bilirubin levels (<jats:italic>r<\/jats:italic>\u00a0=\u20090.534; <jats:italic>p<\/jats:italic>\u00a0=\u20090.013) on hospital admission. Angiopoietin\u20102 showed significant correlation with creatinine levels (<jats:italic>r<\/jats:italic>\u00a0=\u20090.513; <jats:italic>p<\/jats:italic>\u00a0=\u20090.009) on hospital admission and with number of haemodialysis sessions (<jats:italic>r<\/jats:italic>\u00a0=\u20090.406; <jats:italic>p<\/jats:italic>\u00a0=\u20090.049). No significant correlation was found with FGF\u201023. Regarding prognostic performance, combined syndecan\u20101 and angiopoietin\u20102 levels had a better ability to predict haemodialysis need in patients with severe leptospirosis (AUC\u2010ROC\u00a0=\u00a00.744 [95% CI: 0.545\u20130.943] <jats:italic>p<\/jats:italic>\u00a0=\u20090.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Syndecan\u20101 and angiopoietin\u20102 were associated with haemodialysis need in patients with severe leptospirosis and may be useful to improve therapeutic approach and reduce mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13796","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T04:43:10Z","timestamp":1656391390000},"page":"727-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil's disease)"],"prefix":"10.1111","volume":"27","author":[{"given":"Gdayllon Cavalcante","family":"Meneses","sequence":"first","affiliation":[{"name":"Medical Sciences Post\u2010Graduate Program Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Eduardo Andrade","family":"de Carvalho Gomes","sequence":"additional","affiliation":[{"name":"Medical Sciences Post\u2010Graduate Program Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Studart","family":"Galdino","sequence":"additional","affiliation":[{"name":"Medical Sciences Post\u2010Graduate Program Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Freire","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Pharmacology Post\u2010Graduate Program Federal University of Cear\u00e1  Fortaleza 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