{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:22:29Z","timestamp":1791994949799,"version":"4.4.0"},"reference-count":73,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:00:00Z","timestamp":1663632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013986","name":"Government of the United Kingdom","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013986","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To summarise latent tuberculosis infection (LTBI) management strategies among household contacts of bacteriologically confirmed pulmonary tuberculosis (TB) patients in high\u2010TB burden countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed\/MEDLINE (NCBI) and Scopus were searched (January 2006 to December 2021) for studies reporting primary data on LTBI management. Study selection, data management and data synthesis were protocol\u2010driven (PROSPERO\u2010CRD42021208715). Primary outcomes were the proportions of LTBI, initiating and completing tuberculosis preventive treatment (TPT). Reported factors influencing the LTBI care cascade were qualitatively synthesised.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 3694\u00a0unique records retrieved, 58 studies from 23 countries were included. Most identified contacts were screened (median 99%, interquartile range [IQR] 82%\u2013100%; 46 studies). Random\u2010effects meta\u2010analysis yielded pooled proportions for: LTBI 41% (95% confidence interval [CI] 33%\u201349%; 21,566 tested contacts); TPT initiation 91% (95% CI 79%\u201397%; 129,573 eligible contacts, 34 studies); TPT completion 65% (95% CI 54%\u201374%; 108,679 TPT\u2010initiated contacts, 28 studies). Heterogeneity was significant (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009\u2265\u200995%\u2013100%) and could not be explained in subgroup analyses. Median proportions (IQR) were: LTBI 44% (28%\u201359%); TPT initiation 86% (60%\u2013100%); TPT completion 68% (44%\u201382%). Nine broad themes related to diagnostic testing, health system structure and functions, risk perception, documentation and adherence were considered likely to influence the LTBI care cascade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proportions of household contacts screened, detected with LTBI and initiated on TPT, though variable was high, but the proportions completing TPT were lower indicating current strategies used for LTBI management in high TB burden countries are not sufficient.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.13808","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T01:26:00Z","timestamp":1659662760000},"page":"842-863","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Strategies to detect and manage latent tuberculosis infection among household contacts of pulmonary\n                    <scp>TB<\/scp>\n                    patients in high\n                    <scp>TB<\/scp>\n                    burden countries \u2010 a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"27","author":[{"given":"Karuna Devi","family":"Sagili","sequence":"first","affiliation":[{"name":"International Union Against Tuberculosis and Lung Disease South East Asia Office  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malaisamy","family":"Muniyandi","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR) National Institution for Research in Tuberculosis  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpita","family":"Shringarpure","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Medical College Baroda  Baroda India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita","family":"Singh","sequence":"additional","affiliation":[{"name":"International Union Against Tuberculosis and Lung Disease South East Asia Office  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kirubakaran","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Christian Medical Centre  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghuram","family":"Rao","sequence":"additional","affiliation":[{"name":"National TB Elimination Program, Central TB Division Ministry of Health  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamhoih","family":"Tonsing","sequence":"additional","affiliation":[{"name":"Technical Advice and Partnerships Department The Global Fund  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep Singh","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"International Union Against Tuberculosis and Lung Disease South East Asia Office  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prathap","family":"Tharyan","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Christian Medical Centre  Vellore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Global tuberculosis report","year":"2021"},{"key":"e_1_2_8_3_1","volume-title":"The end TB strategy","year":"2014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30216-X"},{"key":"e_1_2_8_5_1","volume-title":"Latent tuberculosis infection: updated and consolidated guidelines for programmatic management","year":"2018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002152"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00070812"},{"key":"e_1_2_8_8_1","volume-title":"WHO consolidated guidelines on tuberculosis. 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