{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:40:22Z","timestamp":1778859622416,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Mycetoma is a neglected tropical disease caused by more than 70 different microorganisms and identified by the WHO as one of the high\u2010priority diseases for developing diagnostic tests. To ensure the production of diagnostic assays for use by clinical staff in endemic regions, target product profiles (TPPs) were designed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the development of two TPPs: one for a diagnostic test able to identify the causative agent of mycetoma and another that would determine when treatment could be stopped. The TPPs were developed by considering product use, design, performance, product configuration and costs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Version 1.0 TPPs for two uses were posted by WHO for a 1\u2010month online public consultation on 25 October 2021, and the final TPP was posted online on 5 May 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A major difficulty encountered in developing both TPPs was the large number of agents able to cause mycetoma and the lack of specific biomarkers for most of them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13828","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T05:14:20Z","timestamp":1667538860000},"page":"1059-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Diagnostics to support mycetoma management\u2014Development of two target product profiles"],"prefix":"10.1111","volume":"27","author":[{"given":"Noah","family":"Fongwen","sequence":"first","affiliation":[{"name":"Department of Clinical Research, Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kingsley B.","family":"Asiedu","sequence":"additional","affiliation":[{"name":"Department of Control of Neglected Tropical Diseases WHO  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Bakhiet","sequence":"additional","affiliation":[{"name":"Mycetoma Research Center Soba University Hospital  Khartoum Sudan"},{"name":"Institute of Endemic Diseases University of Khartoum  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandro","family":"Bonifaz","sequence":"additional","affiliation":[{"name":"Dermatology Service &amp; Mycology Department Hospital General de M\u00e9xico  Cuauht\u00e9moc Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Cruz","sequence":"additional","affiliation":[{"name":"National School of Public Health, CIBERINFEC Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Argaw","sequence":"additional","affiliation":[{"name":"Department of Control of Neglected Tropical Diseases WHO  Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Estrada\u2010Chavez","sequence":"additional","affiliation":[{"name":"Community Dermatology Mexico C.A.\/Faculty of Medicine Universidad Autonoma de Guerrero  Acapulco Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed H.","family":"Fahal","sequence":"additional","affiliation":[{"name":"Mycetoma Research Center Soba University Hospital  Khartoum Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Litvintseva","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases Centers for Disease Control and Prevention  Atlanta USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine  London UK"},{"name":"Infectious Diseases and General Medicine Hospital for Tropical Diseases  London UK"},{"name":"Division of Infection and Immunity University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario C.","family":"Salinas\u2010Carmona","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda Universidad Aut\u00f3noma de Nuevo Le\u00f3n, Facultad de Medicina  Nuevo Le\u00f3n Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doudou","family":"Sow","sequence":"additional","affiliation":[{"name":"Service de Parasitologie\u2010Mycologie, UFR Sciences de la Sant\u00e9 Universit\u00e9 Gaston Berger  Saint\u2010Louis Senegal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy W. 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