{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:53:02Z","timestamp":1776279182651,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report six cases of<jats:italic>Rhizopus homothallicus<\/jats:italic>rhino\u2010orbital\u2010cerebral mucormycosis in North India between April 2021 and July 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Details<\/jats:title><jats:p>All six patients had diabetes, concomitant SARS\u2010CoV\u20102 infection, a history of oxygen requirement and steroid intake. Among these six cases 4 were female. All patients presented with sinus pain and peri\u2010orbital swelling. COVID\u201019\u2010associated mucormycosis (CAM) was diagnosed based on microbiological examination of the biopsied tissue, and its staging was determined radiologically by CT and MRI. Three patients were in stage III\u2010C, the others were in stage II\u2010C, II\u2010D and IV\u2010A. A multidisciplinary team treated the patients with extensive surgical debridement of the affected tissue, correction of predisposing comorbidities and administration of an antifungal agents. Patients were followed up for 6\u00a0months with routine direct nasal endoscopy to check the sinonasal cavity for any recurrence. All the six patients survived at 6\u2009months of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A timely initiated multidisciplinary team\u2010based approach can reduce the mortality in rhino\u2010orbital\u2010cerebral mucormycosis cases caused by<jats:italic>R.\u00a0homothallicus<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13841","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T05:19:40Z","timestamp":1671081580000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Rhizopus homothallicus<\/i>rhino\u2010orbital\u2010cerebral mucormycosis: Six cases from a tertiary care Centre, North India"],"prefix":"10.1111","volume":"28","author":[{"given":"Munesh Kumar","family":"Gupta","sequence":"first","affiliation":[{"name":"Mycology Lab, Department of Microbiology Banaras Hindu University Institute of Medical Sciences Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Banaras Hindu University Institute of Medical Sciences Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ragini","family":"Tilak","sequence":"additional","affiliation":[{"name":"Mycology Lab, Department of Microbiology Banaras Hindu University Institute of Medical Sciences Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University Banaras Hindu University Institute of Medical Sciences Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Banaras Hindu University Institute of Medical Sciences Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Chakravarty","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University Banaras Hindu University Varanasi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycres.2007.03.004"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/oso\/9780195148091.003.0015","volume-title":"Clinical mycology","author":"Ibrahim AS","year":"2003"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70316-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_2269_19"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1392_21"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1565_21"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108284"},{"key":"e_1_2_5_10_1","unstructured":"Mucormycosis \u2010 WHO | World Health Organization.Coronavirus\u2010disease\u2010(COVID\u201419) Of COVID\u2010\u201019 associated mucormycosis and the Government of India. Available from URL:https:\/\/www.who.int\/india\/emergencies\/coronavirus-disease-(COVID--19)\/mucormycosis."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1165_21"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00056-10"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-017-0153-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-017-0151-7"},{"key":"e_1_2_5_16_1","first-page":"23","article-title":"A rare case of pulmonary mucormycosis caused by Rhizopus homothallicus in post heart transplant patient","volume":"6","author":"Taneja J","year":"2020","journal-title":"J Intensive Crit Care"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01272-09"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmmb.2021.06.013"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01087-20"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3AB0718-255R"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.13175"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.13841","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T01:15:46Z","timestamp":1701566146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/tmi.13841"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13841","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"2022-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}