{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:04:49Z","timestamp":1747188289858,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Both linezolid and vancomycin are approved by USFDA and IDSA guidelines for the management of nosocomial pneumonia due to methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) in clinical practice. Baseline creatinine clearance is the criterion for prescribing vancomycin or linezolid for hospital\u2010acquired pneumonia in our institution. However, patients with renal function impairment are far more difficult to manage in intensive care. Thus, the objectives of the study were to compare the clinical efficacy and safety of 600\u2009mg of fixed\u2010dose linezolid with intermittent dose\u2010optimised vancomycin in hospital\u2010acquired pneumonia due to MRSA and to evaluate parameters of clinical cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysis of a review of patients' charts. Patients with creatinine clearance &lt;80\u2009ml\/min received 600\u2009mg linezolid\/12\u2009h (<jats:italic>n\u2009=<\/jats:italic>\u00a0139, LN cohort), and patients with creatinine clearance \u226580\u2009ml\/min received intravenous 15\u2009mg\/kg vancomycin\/12\u2009h for 1\u20132\u2009weeks consecutively or 3\u2009weeks in case of bacteremia (<jats:italic>n\u2009=<\/jats:italic>\u00a0152, VC cohort) for management of hospital\u2010acquired pneumonia due to MRSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 59% of patients from the LN cohort and 47% of patients from the VC cohort were clinically cured. Administration of systemic steroids (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0412) and\u2009\u2265\u200980\u2009ml\/min creatinine clearance (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0498) were the independent parameters for the clinical cure of patients. Nephrotoxicity was higher among patients of the VC cohort than the LN cohort (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0464). Treatment failed in 41% of patients from the LN cohort and in 53% of patients from the VC cohort (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0200).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 600\u2009mg of fixed\u2010dose linezolid is an ideal alternative to intermittent dose\u2010optimised vancomycin for better clinical outcomes for patients with hospital\u2010acquired pneumonia due to MRSA, especially for patients with renal impairment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13866","type":"journal-article","created":{"date-parts":[[2023,3,5]],"date-time":"2023-03-05T12:38:55Z","timestamp":1678019935000},"page":"315-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 600\u2009mg of fixed\u2010dose linezolid in renally impaired patients versus 15\u2009mg\/kg intermittent dose\u2010optimized vancomycin in renally non\u2010impaired patients: A single centre retrospective analysis for adult patients with hospital\u2010acquired pneumonia due to methicillin\u2010resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-0262","authenticated-orcid":false,"given":"Mengqin","family":"Wang","sequence":"first","affiliation":[{"name":"Emergency Department JiShuiTan Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-2450","authenticated-orcid":false,"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Emergency Department JiShuiTan Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5710-6429","authenticated-orcid":false,"given":"Zhaoxing","family":"Tian","sequence":"additional","affiliation":[{"name":"Emergency Department JiShuiTan Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0581-y"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir895"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131932"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw353"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201020666190319161511"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks153"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063-018-0494-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw254"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-561"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13972"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06701-11"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2013.08.001"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1779-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2013.09.011"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1390"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13914"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.12.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-011-0309-z"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir034"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.12.036"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01548-10"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03147-14"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S121513"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211005965"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00356-16"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0525-x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12010054"}],"container-title":["Tropical Medicine &amp; 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