{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:04:50Z","timestamp":1747188290395,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the presence of cross\u2010reactivity by anti\u2010severe acute respiratory syndrome coronavirus 2 antibodies induced by the Pfizer\u2010BioNTech vaccine against <jats:italic>Trypanosoma cruzi<\/jats:italic> proteins in a screening test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three serum samples were obtained from personnel at the Hospital General Naval de Alta Especialidad in Mexico City who received one or two doses of the vaccine and were tested for <jats:italic>T. cruzi<\/jats:italic> infection using four tests: two \u2018in house\u2019 enzyme\u2010linked immunosorbent assays (ELISAs), a commercial ELISA diagnostic kit and an immunoblot test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IgG antibodies against the <jats:italic>T. cruzi<\/jats:italic> proteins were present in the serum of unvaccinated subjects and subjects who had received one or two doses of the vaccine. The positivity of the samples against <jats:italic>T. cruzi<\/jats:italic> was ruled out by means of a Western Blot assay, where all samples were negative for <jats:italic>T. cruzi<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that people convalescing from coronavirus disease 2019 and those who received the Pfizer\u2010BioNTech vaccine exhibit cross\u2010reactive antibodies against <jats:italic>T. cruzi<\/jats:italic> antigens in ELISA assays.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13869","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T04:24:54Z","timestamp":1678163094000},"page":"384-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>Pfizer\u2010BioNTech<\/scp> vaccine induces the production of cross\u2010reactive antibodies against <i>Trypanosoma cruzi<\/i> proteins: A preliminary study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-2910","authenticated-orcid":false,"given":"Aracely","family":"L\u00f3pez\u2010Monteon","sequence":"first","affiliation":[{"name":"LADISER Inmunolog\u00eda y Biolog\u00eda Molecular, Facultad de Ciencias Qu\u00edmicas Universidad Veracruzana  Orizaba Mexico"},{"name":"Asociacion Chagas con Ciencia y Conocimiento A.C. 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