{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:23:24Z","timestamp":1790681004437,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of signs and symptoms of HTLV\u20101 and 2 infection in paediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included cohort, case\u2010control and descriptive observational studies that reported the prevalence of signs and symptoms of HTLV\u20101 and 2 infections in paediatric patients. Searches were performed in MEDLINE\u00ae (Ovid), EMBASE and LILACS from inception to the present, and we saturated information with other sources of published and unpublished literature. We decided not to perform meta\u2010analysis according to heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of eight studies met the inclusion criteria for qualitative analysis. No studies of HTLV\u20102 were found. Females predominated and there was vertical transmission in nearly 100% of cases. Infective dermatitis was a common manifestation of HTLV in paediatric patients. In addition, persistent hyperreflexia, clonus and the Babinski sign were early neurological alterations observed in patients carrying the virus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HTLV screening is recommended in patients presenting infective dermatitis, persistent hyperreflexia, walking disturbances and in those who come from endemic zones.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13879","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T05:04:09Z","timestamp":1682571849000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Signs and symptoms of human T\u2010lymphotropic virus 1 and 2 infections in paediatric patients"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-5485","authenticated-orcid":false,"given":"Christian Andr\u00e9s","family":"Rojas Cer\u00f3n","sequence":"first","affiliation":[{"name":"Department of Pediatrics Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-5477","authenticated-orcid":false,"given":"Deigober","family":"Galvis Arias","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-8261","authenticated-orcid":false,"given":"Herney Andr\u00e9s","family":"Garc\u00eda\u2010Perdomo","sequence":"additional","affiliation":[{"name":"Division of Urology\/Urooncology, Department of Surgery School of Medicine, Universidad del Valle  Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01124"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/341251"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.4.439"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.05.027"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(97)90208-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/380567"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.2.e136"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/432058"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/430064"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis273"},{"key":"e_1_2_6_13_1","volume-title":"Mother\u2010to\u2010child transmission of human T\u2010cell lymphotropic virus types I and II (HTLV\u20101\/11) in Gabon: a prospective follow\u2010up of 4\u2009years","author":"Nyambi PN","year":"1996"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-13-11"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70081-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.04.006"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2012.06.007"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/508177"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2013.0086"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1995.tb01689.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.855"},{"key":"e_1_2_6_22_1","first-page":"932","article-title":"S\u00edndrome cerebelar y neuropat\u00eda perif\u00e9rica como manifestaci\u00f3n de la infecci\u00f3n por el virus linfotr\u00f3pico humano de c\u00e9lulas T","volume":"29","author":"Carod\u2010Artal FJ","year":"1999","journal-title":"HTLV\u2010I Rev Neurol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1201-9712(02)90132-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289509111010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1993.tb04188.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.191239"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1086\/423957"},{"key":"e_1_2_6_28_1","first-page":"67","article-title":"Manifestaciones cut\u00e1neas asociadas con el HTLV\u20101","volume":"22","author":"D\u00edaz CJ","year":"2014","journal-title":"Rev Asoc Colomb Dermatol"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1086\/524695"},{"key":"e_1_2_6_30_1","volume-title":"Mandell, Douglas, and Bennett's principles and practice of infectious diseases","author":"Bennett JE"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153462"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04008.x"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T20:30:00Z","timestamp":1692563400000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/tmi.13879"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13879","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"assertion":[{"value":"2023-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}