{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:28:08Z","timestamp":1781796488780,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven hundred seventy\u2010nine serum samples were tested for anti\u2010diphtheria and anti\u2010tetanus antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants &gt;16\u2009years were more likely to be protected against diphtheria (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and tetanus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13882","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:03:40Z","timestamp":1684411420000},"page":"501-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Low seroprotection against diphtheria and tetanus in Lao adolescents"],"prefix":"10.1111","volume":"28","author":[{"given":"Sonephet","family":"Vantava","sequence":"first","affiliation":[{"name":"Lao Tropical and Public Health Institute, Ministry of Health  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hefele","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunity Luxembourg Institute of Health  Esch\u2010sur\u2010Alzette Grand\u2010Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriphone","family":"Virachith","sequence":"additional","affiliation":[{"name":"Lao\u2010Lux Laboratory Institut Pasteur du Laos  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souphaphone","family":"Vannachone","sequence":"additional","affiliation":[{"name":"Lao Tropical and Public Health Institute, Ministry of Health  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilaysone","family":"Khounvisith","sequence":"additional","affiliation":[{"name":"Lao\u2010Lux Laboratory Institut Pasteur du Laos  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phonethipsavanh","family":"Nouanthong","sequence":"additional","affiliation":[{"name":"Lao\u2010Lux Laboratory Institut Pasteur du Laos  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"H\u00fcbschen","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunity Luxembourg Institute of Health  Esch\u2010sur\u2010Alzette Grand\u2010Duchy of Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somphou","family":"Sayasone","sequence":"additional","affiliation":[{"name":"Lao Tropical and Public Health Institute, Ministry of Health  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony P.","family":"Black","sequence":"additional","affiliation":[{"name":"Lao\u2010Lux Laboratory Institut Pasteur du Laos  Vientiane Lao People's Democratic Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"issue":"31","key":"e_1_2_7_2_1","first-page":"417","article-title":"Diphtheria vaccine: WHO position paper","volume":"92","author":"WHO","year":"2017","journal-title":"Wkly Epidemiol Rec"},{"key":"e_1_2_7_3_1","unstructured":"The Centers for Disease Prevention and Control.Pinkbook: Tetanus | CDC [Internet]. [cited 2023 Mar 14]. Available from:https:\/\/www.cdc.gov\/vaccines\/pubs\/pinkbook\/tetanus.html"},{"key":"e_1_2_7_4_1","unstructured":"World Health Organization.Tetanus [Internet]. [cited 2020 Jun 18]. Available from:https:\/\/www.who.int\/health-topics\/tetanus\/#tab=tab_1"},{"issue":"6","key":"e_1_2_7_5_1","first-page":"53","article-title":"Tetanus vaccines: WHO position paper \u2013 February 2017","volume":"92","author":"WHO","year":"2017","journal-title":"Wkly Epidemiol Rep"},{"key":"e_1_2_7_6_1","unstructured":"Lao Statistics Bureau.Statistical Yearbook 2018 [Internet]. Yearbook 2018. Vientiane Lao PDR.2019. Available from:https:\/\/www.lsb.gov.la\/en\/"},{"key":"e_1_2_7_7_1","unstructured":"Lao Statistics Bureau.Lao Social Indicator Survey II 2017: Survey Findings Report. 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