{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:42:45Z","timestamp":1757540565528,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We present a case of primary cutaneous mucormycosis in a patient with bone marrow failure secondary to paroxysmal nocturnal haemoglobinuria (PNH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical case<\/jats:title><jats:p>A 60\u2010year\u2010old male patient with a history of PNH, complicated to a severe aplastic anaemia, presented to the emergency department complaining of papules on the lower limbs that rapidly turned into necrotic plaques within 2\u2009months. Histopathological examination showed granulomatous and suppurative dermatitis with tissue necrosis and the presence of non\u2010septate hyphae. Molecular identification was achieved by amplification and sequencing of the 18S\u2010ITS1\u20105.8S\u2010ITS2\u201028S rRNA region using the polymerase chain reaction. The sequence showed 100% identity with <jats:italic>Rhizopus arrhizus<\/jats:italic>. The patient received treatment with liposomal amphotericin B and surgical debridement. Nonetheless, the patient suffered from severe low red blood cells and platelets and also underwent septic shock; he died 6\u2009days after admission to the hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mucormycosis in the setting of immunosuppression is challenging. Upon suspicion of a diagnosis, immediate treatment is required. Adjunctive therapies may be considered; however, the case fatality rate remains high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13898","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:30Z","timestamp":1685059230000},"page":"580-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary cutaneous mucormycosis due to <i>Rhizopus arrhizus<\/i> in an immunosuppressed patient with paroxysmal nocturnal haemoglobinuria"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-026X","authenticated-orcid":false,"given":"Ilse Yolanda","family":"Osorio\u2010Arag\u00f3n","sequence":"first","affiliation":[{"name":"Departmento de Dermatolog\u00eda Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6883-3100","authenticated-orcid":false,"given":"Sonia","family":"Toussaint\u2010Caire","sequence":"additional","affiliation":[{"name":"Departmento de Dermatolog\u00eda Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8092-9327","authenticated-orcid":false,"given":"Sim\u00f3n","family":"Guzm\u00e1n\u2010Bucio","sequence":"additional","affiliation":[{"name":"Departmento de Medicina Interna Hospital M\u00e9dica Sur  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-3519","authenticated-orcid":false,"given":"Bibiana Monserrat","family":"Barbosa\u2010Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departmento de Medicina Interna Hospital M\u00e9dica Sur  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-5945","authenticated-orcid":false,"given":"V\u00edctor A.","family":"V\u00e1zquez\u2010Aceituno","sequence":"additional","affiliation":[{"name":"Departmento de Ecolog\u00eda de Agentes Pat\u00f3genos Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-9973","authenticated-orcid":false,"given":"Juan","family":"Xicohtencatl\u2010Cortes","sequence":"additional","affiliation":[{"name":"Laboratorio de Bacteriolog\u00eda Intestinal Hospital Infantil de M\u00e9xico Dr. Federico G\u00f3mez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rigoberto","family":"Hern\u00e1ndez\u2010Castro","sequence":"additional","affiliation":[{"name":"Departmento de Ecolog\u00eda de Agentes Pat\u00f3genos Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez\u201d  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5010026"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040265"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2017.07.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02930961"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13508"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx017"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-015-0236-z"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8020194"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2020.101007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2005.tb00761.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2007.01010.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.22370\/bolmicol.2008.23.0.120"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12715"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0084-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7040271"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"}],"container-title":["Tropical Medicine &amp; 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