{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:48:04Z","timestamp":1785858484003,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p><jats:italic>Neisseria meningitidis<\/jats:italic> is one of the major pathogens of meningitis in children worldwide and causes invasive meningococcal disease (IMD), which is a critical illness that mainly presents as meningitis and\/or septicemia in children. Identification of <jats:italic>N. meningitidis<\/jats:italic> in cerebrospinal fluid (CSF) is the gold standard for the diagnosis of meningococcal meningitis, but antigen tests have advantages such as timely results, relatively low cost, and convenience. Yet, the diagnostic accuracy of antigen tests remains uncertain. Therefore, the aim of this meta\u2010analysis was to evaluate the diagnostic accuracy of antigen tests for <jats:italic>N. meningitidis<\/jats:italic> in CSF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, Embase, and Cochrane Library databases for studies evaluating the diagnostic accuracy of antigen tests for <jats:italic>N. meningitidis<\/jats:italic> in CSF. We included studies that provided sufficient data to construct a 2\u2009\u00d7\u20092 table on a per\u2010sample basis. To determine the overall sensitivity and specificity of the antigen tests, we used polymerase chain reaction (PCR) as the reference standard and employed the hierarchical summary receiver operating characteristic model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies with 4533 CSF samples were included. The meta\u2010analysis yielded a pooled sensitivity of 91.2% (95% confidence interval [CI]: 80.0%\u2013100.0%) and a pooled specificity of 93.8% (95% CI: 83.9%\u2013100.0%). A subgroup analysis of 2 studies that reported the outcomes of MeningoSpeed yielded a pooled sensitivity of 93.4% (95% CI: 90.0%\u201395.8%) and a pooled specificity of 91.9% (95% CI: 88.6%\u201394.4%). Antigen testing for the <jats:italic>N. meningitidis<\/jats:italic> serogroup X had a pooled sensitivity of 92.4% (95% CI: 85.2%\u201396.2%) and a pooled specificity of 99.2% (95% CI: 78.7%\u2013100.0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The studied antigen tests had high sensitivity and specificity for the diagnosis of meningococcal meningitis in CSF specimens. Antigen testing could serve as an accurate diagnostic method for assessing patients who have a suspected <jats:italic>N. meningitidis<\/jats:italic> infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13928","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:07:08Z","timestamp":1693289228000},"page":"797-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Accuracy of antigen tests for meningococcal meningitis in cerebrospinal fluid: A diagnostic meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Hsiu\u2010Ling","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Nursing Landseed International Hospital  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Mei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Nursing Landseed International Hospital  Taoyuan 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