{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T01:40:44Z","timestamp":1771724444924,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["1309\u201000003B"],"award-info":[{"award-number":["1309\u201000003B"]}],"id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R209\u20102015\u20103580"],"award-info":[{"award-number":["R209\u20102015\u20103580"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Anaemia during pregnancy is a major health challenge affecting pregnancy outcome worldwide. The objectives of this study were to investigate the impact of severe\u2013moderate anaemia in the first trimester, as well as changes in haemoglobin during pregnancy among non\u2010anaemic women, on foetal weight, placental blood flow and newborn anthropometrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective cohort study, 346 women residing in rural Tanzania were followed throughout pregnancy with serial ultrasound and newborn anthropometrics assessed within 24\u2009h of delivery. Associations between placental blood flow, foetal weight and newborn anthropometrics with either first trimester severe\u2013moderate anaemia (haemoglobin\u22649.5\u2009g\/dL) or changes in haemoglobin from the first to the third trimester among non\u2010anaemic women, were assessed by mixed model regression and multiple linear regression, adjusting for maternal and foetal co\u2010variables. Foetal weights and birthweight were converted to <jats:italic>z<\/jats:italic>\u2010scores using a population based sex\u2010specific weight reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe\u2013moderate anaemia in the first trimester was associated with significantly reduced foetal weight <jats:italic>z<\/jats:italic>\u2010scores (adjusted mean difference (aMD) \u22120.44 (95% CI \u22120.81, \u22120.07)) and newborn anthropometric indices (birth weight <jats:italic>z<\/jats:italic>\u2010score aMD \u22120.55 (\u22120.9, \u22120.13), abdominal circumference aMD \u221211\u2009mm (95% CI \u221220, \u22123)). There were no association between first trimester severe\u2013moderate anaemia and placental blood flow.<\/jats:p><jats:p>Among women who were non\u2010anaemic in the first trimester, women with the least reduction in haemoglobin (\u0394\u2009\u2265\u2009\u22120.3\u2009g\/dL) delivered significantly smaller newborns (birthweight <jats:italic>z<\/jats:italic>\u2010score aMD \u22120.55 (\u22120.91, \u22120.20), abdominal circumference aMD \u221210\u2009mm (95% CI \u221217, \u22123), compared to women with the greatest reduction (\u0394 haemoglobin \u2264\u2009\u22121.4\u2009g\/dL)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Severe\u2013moderate anaemia in early pregnancy was associated with smaller newborn anthropometrics which was reflected in smaller mean foetal weights in the second and third trimester. Furthermore, among women who were non\u2010anaemic in the first trimester, there was an association between smaller newborn anthropometrics and limited haemoglobin decrease during pregnancy, possibly reflecting insufficient plasma expansion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13967","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T01:59:47Z","timestamp":1704765587000},"page":"243-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anaemia in the first trimester and poor physiological plasma expansion during pregnancy negatively impact foetal weight and newborn anthropometrics: An observational cohort study in <scp>Tanzania<\/scp>"],"prefix":"10.1111","volume":"29","author":[{"given":"Christentze","family":"Schmiegelow","sequence":"first","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology University of Copenhagen  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