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Therefore, this study aims to systematically review the literature to identify the risk factors associated with severe dengue in Latin America through systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, SciELO, LILACS and EMBASE databases were used to search for eligible scientific articles for the review. The outcomes considered were symptoms of severe dengue, hospitalisation and death. The Joanna Briggs Institute Critical Appraisal Checklist was used to assess the quality of the studies. Data analysis was performed using STATA v 13.0 software. The degree of heterogeneity between studies was quantified using the <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> measure, and statistically significant results were defined as those with <jats:italic>p<\/jats:italic> values &lt;0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1876 articles screened, 47 articles were included in the systematic review and 45 articles were analysed through meta\u2010analysis. Identified risk factors associated with severe dengue included secondary dengue infection, female sex, white or Caucasian ethnicity and specific signs and symptoms such as headache, myalgia and\/or arthralgia, vomiting\/nausea, abdominal pain or tenderness, diarrhoea, prostration, lethargy, fatigue or similar. For the death outcome, respiratory symptoms and age &lt;18\u2009years were identified as risk factors. On the other hand, in women, the diagnosis of positive tourniquet test, platelet count &lt;100,000 per \u03bcL and symptoms of capillary fragility were associated with a lower probability of death. These data highlight the importance of early screening of patients, to identify possible haemorrhagic signs and reduce deaths from dengue. This study has limitations, including possible publication bias, heterogeneity of results and study design biases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings are significant for shaping strategies, management approaches and identifying high\u2010risk groups, which will help establish future guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13968","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T02:29:46Z","timestamp":1706063386000},"page":"173-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Risk factors associated with severe dengue in Latin America: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-2518","authenticated-orcid":false,"given":"Victoria Cruz","family":"Paran\u00e1","sequence":"first","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Bahia Brazil"},{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1891-1337","authenticated-orcid":false,"given":"Caroline Alves","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-6344","authenticated-orcid":false,"given":"Greice Carolina Santos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-3558","authenticated-orcid":false,"given":"Luana Leandro","family":"Gois","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Bahia Brazil"},{"name":"Department of Biointeraction Sciences, Institute of Health Sciences Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-3495","authenticated-orcid":false,"given":"Luciane Amorim","family":"Santos","sequence":"additional","affiliation":[{"name":"Bahiana School of Medicine and Public Health  Salvador Bahia Brazil"},{"name":"Gon\u00e7alo Moniz Institute, Oswaldo Cruz Foundation  Salvador Bahia Brazil"},{"name":"Graduate Program in Health Sciences, College of Medicine of Bahia Federal University of Bahia  Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2007.07.002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAF.0000000000000236"},{"key":"e_1_2_7_4_1","unstructured":"WHO.Dengue and Severe Dengue. 2022 Jan 10. 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