{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:12:30Z","timestamp":1759497150301,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009660","name":"London School of Hygiene and Tropical Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD095562"],"award-info":[{"award-number":["R01HD095562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Schistosomiasis is persistent in Lake Albert, Uganda, but local data are limited. This study aims to describe the local burden of moderate\u2010to\u2010heavy infection and associated morbidity in all ages and identify factors associated with these outcomes to guide further research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional pilot study was conducted in July\u2013August, 2022 in four village sites (Walukuba, Rwentale, Kyabarangwa and Runga) of the Praziquantel in Preschoolers (PIP) trial. Residents (approximately four per household) of any age of households of PIP participants were eligible, but individuals &lt;10\u2009years were only enrolled if no older individuals were available. Socio\u2010demographic information, household location, single stool Kato\u2010Katz and hepatic ultrasound results were obtained for a convenience sampled subset of trial households. The primary outcome, moderate\u2010to\u2010heavy infection (\u2265100 eggs per gram of faeces), was analysed using mixed\u2010effects logistic regression, with a household random effect. Univariate analyses were used for the secondary outcome, periportal fibrosis (Niamey protocol ultrasound image pattern C\u2013F).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 243 participants with a median age of 22 (interquartile range 12\u201333) years from 66 households, 49.8% (103\/207 with a Kato\u2010Katz result) had moderate\u2010to\u2010heavy infection and 11.2% (25\/224 with ultrasound data) had periportal fibrosis. Moderate\u2010to\u2010heavy infection clustered by household (intraclass correlation coefficient\u2009=\u20090.11) and, in multivariable analysis, varied by village (Walukuba vs. Kyabarangwa adjusted odds ratio [aOR] 0.11, 95% CI 0.02\u20130.71), was highest in participants aged 10\u201315\u2009years (vs. 5\u20139\u2009years aOR 6.14, 95% CI 1.61\u201323.38) and lower in those reporting praziquantel treatment in the past year (aOR 0.39, 95% CI 0.18\u20130.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this setting, schistosome infection and morbidity are pervasive in all age groups. More intensive interventions are needed, for example more frequent praziquantel treatment, under investigation in the PIP trial and improved water and sanitation. More research is needed to understand local treatment barriers and optimal control strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13978","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T08:49:29Z","timestamp":1707986969000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A cross\u2010sectional pilot household study of <i>Schistosoma mansoni<\/i> burden and associated morbidities in Lake Albert, Uganda"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-3851","authenticated-orcid":false,"given":"Dominic P.","family":"Dee","sequence":"first","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine  London UK"},{"name":"MRC Centre for Global Infectious Disease Analysis Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8095-1989","authenticated-orcid":false,"given":"Germain","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Edielu","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine  London UK"},{"name":"MRC\/UVRI and LSHTM Uganda Research Unit  Entebbe Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Anguajibi","sequence":"additional","affiliation":[{"name":"China\u2010Uganda Friendship Hospital  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4019-7456","authenticated-orcid":false,"given":"Emily L.","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidah","family":"Wamboko","sequence":"additional","affiliation":[{"name":"Vector Control Division  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-8904","authenticated-orcid":false,"given":"Patrice A.","family":"Mawa","sequence":"additional","affiliation":[{"name":"MRC\/UVRI and LSHTM Uganda Research Unit  Entebbe Uganda"},{"name":"Department of Immunology Uganda Virus Research Institute  Entebbe Uganda"},{"name":"Department of Infection Biology London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5804-9921","authenticated-orcid":false,"given":"Jennifer F.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Center for International Health Research Rhode Island Hospital  Providence Rhode Island USA"},{"name":"Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2956-5342","authenticated-orcid":false,"given":"Hope","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Disease Control London School of Hygiene and Tropical Medicine  London UK"},{"name":"Centre for Global Health Research Brighton and Sussex Medical School  Brighton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-4159","authenticated-orcid":false,"given":"Amaya L.","family":"Bustinduy","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32279-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed4030110"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4314\/mejs.v5i1.85339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007617"},{"volume-title":"WHO guideline on control and elimination of human schistosomiasis [Internet]","year":"2022","author":"World Health Organization","key":"e_1_2_9_7_1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2004.06.003"},{"key":"e_1_2_9_9_1","unstructured":"Expanded Special Project for Elimination of Neglected Tropical Diseases. 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