{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:54:58Z","timestamp":1791550498460,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotic prophylaxis to prevent brucellosis after accidental exposure to <jats:italic>Brucella<\/jats:italic> is an important topic in public health. This study aimed to systematically review the efficacy of antibiotic prophylaxis following accidental exposure to <jats:italic>Brucella<\/jats:italic> in preventing human brucellosis disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study protocol was registered in PROSPERO (CRD42023456812). The outcomes included the incidence of brucellosis disease, adverse events rate, and antibiotic prophylaxis adherence. A comprehensive literature search, conducted until 20 November, 2023, involved Medline, Embase, Cochrane Library, and LILACS databases. Descriptive analysis and meta\u2010analysis using R software were performed, risk of bias was assessed using JBI Critical appraisal tools, and certainty of evidence was assessed using the GRADE tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3102 initially identified records, eight studies involving 97 individuals accidentally exposed, all focused on high\u2010risk accidental exposure to <jats:italic>Brucella<\/jats:italic> in laboratory settings, were included in the review. All studies reported the prophylactic treatment comprising doxycycline at a dosage of 100\u2009mg twice daily, combined with rifampicin at 600\u2009mg, both administered over 21\u2009days. Prophylaxis adherence was reported in 86% of cases, and incidence of brucellosis post\u2010treatment was 0.01. Adverse events, mainly gastrointestinal, occurred in 26% of cases. Critical appraisal revealed limitations in reporting demographics and clinical information. The certainty of evidence was rated as \u2018very low,\u2019 emphasising the need for caution in interpreting the observed outcomes due to study design constraints and the absence of comparative groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PEP is an alternative practice reported in the literature, used in accidents with high\u2010risk exposure to <jats:italic>Brucella<\/jats:italic>. The currently available evidence of the efficacy of antibiotic prophylaxis is insufficient to support a recommendation for or against the widespread use of antibiotic prophylaxis, so caution is needed in interpreting results due to the very low certainty of evidence, primarily stemming from case series and lack of comparative groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13992","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T23:06:35Z","timestamp":1713827195000},"page":"454-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of antibiotic prophylaxis to preventing brucellosis in accidental exposure: A systematic review"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-9819","authenticated-orcid":false,"given":"Sarah","family":"Nascimento Silva","sequence":"first","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0538-7403","authenticated-orcid":false,"given":"Glaucia","family":"Cota","sequence":"additional","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9054-4794","authenticated-orcid":false,"given":"Kathiaja Miranda","family":"Souza","sequence":"additional","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9279-0307","authenticated-orcid":false,"given":"Marina Gon\u00e7alves","family":"de Freitas","sequence":"additional","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"},{"name":"SCMED Brazilian Health Regulatory Agency  Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0875-3600","authenticated-orcid":false,"given":"Jana\u00edna de Pina","family":"Carvalho","sequence":"additional","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-3932","authenticated-orcid":false,"given":"Endi Lanza","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"N\u00facleo de Avalia\u00e7\u00e3o de Tecnologias em Sa\u00fade, Grupo de Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Instituto Ren\u00e9 Rachou, Funda\u00e7\u00e3o Oswaldo Cruz  Belo Horizonte Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Reabilita\u00e7\u00e3o e Desempenho Funcional Departamento de Fisioterapia. 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