{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:39Z","timestamp":1787016099842,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2024,6]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n Crimean\u2010Congo haemorrhagic fever (CCHF) is a zoonotic viral infection which is an important public health problem in Turkey. CCHF causes fever and bleeding and can lead to severe health outcomes. The study aims to report a case of a male patient with severe CCHF, hemophagocytic lymphohistiocytosis (HLH) treated with steroids and portal vein thrombosis.<\/jats:p>\n <\/jats:sec>\n \n Case Report<\/jats:title>\n A 37\u2010year\u2010old man was admitted to the emergency department with complaints of high fever, headache, myalgia and diarrhoea. The patient travelled to the endemic region of Turkey. In laboratory findings, thrombocytopenia, abnormal liver function tests and elevated coagulation parameters were observed. Real\u2010time polymerase chain reaction assay was used for diagnosis of CCHF. Hypofibrinogenemia, hypertriglyceridemia, elevated ferritin and d\u2010dimer levels were observed in the clinical follow\u2010up. Prednisolone treatment was performed due to considered the diagnosis of HLH. Portal vein thrombosis was detected on abdominal computed tomography scan. He was successfully treated with ribavirin, corticosteroids, anticoagulant and supportive therapy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The clinical presentation of CCHF can range from self\u2010limiting flu\u2010like to severe symptoms possibly fatal. Acute portal vein embolism is a rare complication that has not been reported before to our knowledge. Corticosteroids may be a life\u2010saving treatment for CCHF patients presenting with HLH.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.13995","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T23:53:26Z","timestamp":1713225206000},"page":"536-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A case of\n Crimean\u2010Congo<\/scp>\n haemorrhagic fever complicated with portal vein thrombosis and hemophagocytosis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-3101","authenticated-orcid":false,"given":"\u00d6zge","family":"\u00c7ayda\u015f\u0131","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ey\u00fcp","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Ad\u0131yeke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taha Yusuf","family":"Kuzan","sequence":"additional","affiliation":[{"name":"Department of Radiology Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Y\u0131lmaz","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya \u00d6zt\u00fcrk","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology Sancaktepe Research and Training Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2004.08.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001485"},{"key":"e_1_2_6_4_1","unstructured":"Crimean\u2010Congo haemorrhagic fever [Internet]. 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