{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:07:45Z","timestamp":1793642865680,"version":"4.5.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic inflammatory disease often associated with serious cardiovascular comorbidities. The aim of this study was to investigate the systemic inflammatory burden in psoriasis by examining various inflammatory markers and to assess the relationship between these markers and the severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study was conducted on medical records of patients who visited the dermatology outpatient clinic between 1 January 2016 and 31 December 2022. The study included patients with psoriasis vulgaris and healthy volunteers. Demographic data, Psoriasis Area and Severity Index score, C\u2010reactive protein, monocyte\u2010high\u2010density lipoprotein cholesterol ratio, neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, monocyte\u2010to\u2010lymphocyte ratio, systemic immune\u2010inflammation index, and Systemic Inflammation Response Index were analysed and compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 278 psoriasis patients and 90 healthy volunteers were analysed. Compared to the control group, psoriasis patients showed significantly higher systemic immune\u2010inflammation index, Systemic Inflammation Response Index, neutrophil\u2010to\u2010lymphocyte ratio, monocyte\u2010high\u2010density lipoprotein cholesterol ratio, serum C\u2010reactive protein levels, neutrophil count, monocyte count, body mass index, and waist circumference (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.014, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.046, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>p<\/jats:italic>\u2009=\u20090.011, respectively). Among patients with severe psoriasis (Psoriasis Area and Severity Index &gt;10), systemic immune\u2010inflammation index, neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, and serum C\u2010reactive protein levels were significantly higher compared to patients with mild\/moderate psoriasis (Psoriasis Area and Severity Index \u226410). In the ROC curve analysis, the optimal cut\u2010off (AUC, sensitivity, specificity) values for neutrophil\u2010to\u2010lymphocyte ratio, systemic immune\u2010inflammation index, and platelet\u2010to\u2010lymphocyte ratio were found to be 2.11 (0.592, 62%, 57%), 552.9 (0.579, 61%, 58%), and 111.9 (0.578, 64%, 46%), respectively. The inflammatory parameters that showed correlation with Psoriasis Area and Severity Index were systemic immune\u2010inflammation index, Systemic Inflammation Response Index, neutrophil\u2010to\u2010lymphocyte ratio, monocyte\u2010high\u2010density lipoprotein cholesterol ratio, monocyte\u2010to\u2010lymphocyte ratio, and C\u2010reactive protein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of this study suggest that systemic immune\u2010inflammation index, Systemic Inflammation Response Index, neutrophil\u2010to\u2010lymphocyte ratio, monocyte\u2010high\u2010density lipoprotein cholesterol ratio, and C\u2010reactive protein values have the potential to serve as simple and cost\u2010effective markers for assessing the inflammatory burden in individuals with psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14052","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T05:24:42Z","timestamp":1729833882000},"page":"971-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Assessing systemic inflammatory markers in psoriasis: A retrospective study"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-2421","authenticated-orcid":false,"given":"Berna","family":"Solak","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine, Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1828-5844","authenticated-orcid":false,"given":"Rabia \u00d6zta\u015f","family":"Kara","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Sakarya University  Sakarya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15159"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18044"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-018-0538-x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jvc2.67"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.25691"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/15593258211064744"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.197"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.1213"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.02.008"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5455\/msm.2014.231-233"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.05.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319717704748"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-123163"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.043"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27028"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0730-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402307"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.019"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.10.006"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.02.008"},{"issue":"3","key":"e_1_2_8_23_1","article-title":"Is there any association between the monocyte\/lymphocyte ratio and the presence and severity of the disease in patients with psoriasis? A cross\u2010sectional study","volume":"10","author":"Co\u015fansu NCSD","year":"2020","journal-title":"Sakarya T\u0131p Dergisi"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03584.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1160\/THS10-11-0720"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12511"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_935_21"},{"issue":"1","key":"e_1_2_8_28_1","first-page":"157","article-title":"Role of neutrophil\u2010to\u2010lymphocyte ratio, platelet\u2010to\u2010lymphocyte ratio, mean platelet volume in Egyptian patients with psoriasis vulgaris","volume":"27","author":"Hammad R","year":"2020","journal-title":"Egypt J Immunol"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13061"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031128"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S378309"},{"issue":"4","key":"e_1_2_8_32_1","first-page":"352","article-title":"Systemic immune\u2010inflammation index (SII) predicts increased severity in psoriasis and psoriatic arthritis","volume":"46","author":"Yorulmaz A","year":"2020","journal-title":"Curr Health Sci J"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14101"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12083046"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2022.06.773"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.14052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T02:38:44Z","timestamp":1733193524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.14052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/tmi.14052"],"URL":"https:\/\/doi.org\/10.1111\/tmi.14052","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"assertion":[{"value":"2024-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}