{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T05:30:07Z","timestamp":1735968607580,"version":"3.32.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effectiveness and cost\u2010effectiveness of integrating seasonal malaria chemoprevention (SMC) with mass drug administration for helminth control among school\u2010aged children living in communities where the burden of malaria and helminths is high in Ghana, West Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cluster randomised controlled trial will enrol 1200 children aged 5\u201310\u2009years. Eligible children randomised to intervention clusters will receive SMC drugs (sulphadoxine\u2010pyrimethamine plus amodiaquine) and anthelminthic drugs for soil\u2010transmitted helminths\u2014(albendazole), and for schistosomiasis (praziquantel), while children randomised to control clusters will receive SMC drugs alone. Pre\u2010 and post\u2010intervention blood, urine and stool samples will be collected from children in both clusters. The effectiveness of the concomitant delivery will be determined by checking whether the combination of SMC and anthelminthic drugs prevents anaemia in the children randomised to the intervention clusters compared to the children in the control clusters. Cost analysis and cost\u2010effectiveness of this integrated delivery approach will be determined by estimating the incremental costs and effects of co\u2010administration of SMC drugs with mass drug administration of anthelminthic drugs compared to SMC alone, including cost savings due to cases of moderate and severe anaemia averted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Expected findings<\/jats:title><jats:p>The findings of this study will provide evidence to inform public health recommendations for an integrated control of malaria and helminths among children living in the poorest countries of the world.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14062","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T09:46:42Z","timestamp":1732700802000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the effectiveness and cost\u2010effectiveness of integrating mass drug administration for helminth control with seasonal malaria chemoprevention in Ghanaian children: Protocol for a cluster randomised controlled trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9967-6419","authenticated-orcid":false,"given":"Muhammed O.","family":"Afolabi","sequence":"first","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-2565","authenticated-orcid":false,"given":"Dennis","family":"Adu\u2010Gyasi","sequence":"additional","affiliation":[{"name":"Research and Development Division Kintampo Health Research Centre  Kintampo Ghana"},{"name":"Centre for Research in Applied Biology, School of Sciences University of Energy and Natural Resources  Sunyani Bono Region Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0689-0473","authenticated-orcid":false,"given":"Lucy","family":"Paintain","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Tawiah","sequence":"additional","affiliation":[{"name":"Research and Development Division Kintampo Health Research Centre  Kintampo Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Sanni","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-9118","authenticated-orcid":false,"given":"Brian","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-351X","authenticated-orcid":false,"given":"Kwaku Poku","family":"Asante","sequence":"additional","affiliation":[{"name":"Research and Development Division Kintampo Health Research Centre  Kintampo Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000270"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.19-0362"},{"issue":"13","key":"e_1_2_7_4_1","article-title":"Safety of seasonal malaria chemoprevention (SMC) with sulfadoxine\u2010pyrimethamine plus amodiaquine when delivered to children under 10\u2009years of age by district health services in Senegal: results from a stepped\u2010wedge cluster randomized trial","volume":"11","author":"Ndiaye J","year":"2016","journal-title":"PLoS Med"},{"volume-title":"Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021\u20132030","year":"2020","author":"World Health Organization","key":"e_1_2_7_5_1"},{"key":"e_1_2_7_6_1","unstructured":"World Health Organization.Updated WHO recommendations for malaria chemoprevention among children and pregnant women [cited 2022 Nov16]. 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