{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:03:26Z","timestamp":1792134206531,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","award":["010\/2021"],"award-info":[{"award-number":["010\/2021"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sporotrichosis is a neglected tropical disease and the most common subcutaneous mycosis, mainly caused by Sporothrix species, particularly <jats:italic>S. brasiliensis, S. schenckii<\/jats:italic> and <jats:italic>S. globosa<\/jats:italic>, which exhibit varying biological behaviours and virulence. The epidemic of sporotrichosis in Brazil, initiated in Rio de Janeiro in the late 1990s, rapidly spread to other states, including Amazonas in 2021. This study aimed to identify the specific Sporothrix species responsible for the human sporotrichosis outbreak in the Brazilian Amazon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted by enrolling clinically suspected cases of sporotrichosis attended at a reference dermatologic centre, in Manaus (Brazil). Biological material was collected from their skin lesions for culture (Mycosel) and for species identification (qPCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sporothrix cultures were obtained from 150 cases. Sporotrichosis predominantly affected females (67.3%), aged 44.5\u2009years on average, with lymphocutaneous lesions (72.7%). <jats:italic>Sporothrix brasiliensis<\/jats:italic> was identified in 89.3% of patients. Up to 83.3% of these patients reported contact with cats previously to the skin lesion, and the time\u2010spatial progression of the human cases followed the notification of cases in cats, in the metropolitan region of Manaus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Sporothrix brasiliensis<\/jats:italic> is the dominant species in the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon, with cats identified as the primary vectors. Effective sanitary control measures, education and responsible pet ownership are crucial to mitigating zoonotic sporotrichosis' impact in Brazil and preventing its spread to neighbouring Latin American cities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14065","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T07:34:46Z","timestamp":1733297686000},"page":"65-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>Sporothrix brasiliensis<\/i> as the major causative species of the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3538-0748","authenticated-orcid":false,"given":"Guilherme Caldas","family":"de Souza","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Dermatologia Universidade do Estado do Amazonas  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0602-9384","authenticated-orcid":false,"given":"Euzenio Moreira","family":"de Brito","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Dermatologia Universidade do Estado do Amazonas  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7336-5786","authenticated-orcid":false,"given":"D\u00e9bora Cristina","family":"de Lima Fernandes","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hospitalar Alfredo da Matta de Dermatologia  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-3302","authenticated-orcid":false,"given":"Maria Zeli Moreira","family":"Frota","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-5393","authenticated-orcid":false,"given":"Felipe Jules","family":"de Ara\u00fajo Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Dermatologia Universidade do Estado do Amazonas  Manaus Amazonas Brazil"},{"name":"Funda\u00e7\u00e3o Hospitalar Alfredo da Matta de Dermatologia  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3069-2434","authenticated-orcid":false,"given":"Cynthia","family":"de Oliveira Ferreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hospitalar Alfredo da Matta de Dermatologia  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-4628","authenticated-orcid":false,"given":"Camila 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Ci\u00eancias Aplicadas \u00e0 Dermatologia Universidade do Estado do Amazonas  Manaus Amazonas Brazil"},{"name":"Funda\u00e7\u00e3o Hospitalar Alfredo da Matta de Dermatologia  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6116","authenticated-orcid":false,"given":"Valderiza Louren\u00e7o","family":"Pedrosa","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias Aplicadas \u00e0 Dermatologia Universidade do Estado do Amazonas  Manaus Amazonas Brazil"},{"name":"Funda\u00e7\u00e3o Hospitalar Alfredo da Matta de Dermatologia  Manaus Amazonas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-9400","authenticated-orcid":false,"given":"Marcelo","family":"Mira","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Sciences School of Medicine and Life Sciences, Pontif\u00edcia 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