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We previously conducted the first investigation on this topic in France with a case series of severe CAP\u2010<jats:italic>Ab<\/jats:italic> in Reunion Island over an eight\u2010year period. In the present work, we aim to highlight the specific aspects of CAP\u2010<jats:italic>Ab<\/jats:italic> by comparing our case series with an historical cohort (PAC_RUN), obtained by retrospective chart review (2016\u20132021) of severe community\u2010acquired pneumonia cases on Reunion Island, in which CAP\u2010<jats:italic>Ab<\/jats:italic> was ruled out. During the study period, eight CAP\u2010<jats:italic>Ab<\/jats:italic> cases were identified, giving an incidence of 0.1 cases per 100,000 people\/year, and an incidence of 16.5 cases per 100,000 people\/year for non\u2010<jats:italic>Ab\u2010<\/jats:italic>related CAP (<jats:italic>n<\/jats:italic>\u2009=\u2009761). By comparing with non\u2010<jats:italic>Ab\u2010<\/jats:italic>related CAP, patients had more excessive alcohol use (75% vs. 25.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and lower body mass index (21 vs. 24\u2009kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Six cases (75%) of CAP\u2010<jats:italic>Ab<\/jats:italic> occurred during the rainy season (<jats:italic>p<\/jats:italic>\u2009=\u20090.06). Mortality was higher (62.5% vs. 24.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and time to death was shorter (median 2\u2009days vs. 7, <jats:italic>p<\/jats:italic>\u2009=\u20090.009) in the CAP\u2010<jats:italic>Ab<\/jats:italic> group. Bacteraemic pneumonia was strongly associated with CAP\u2010<jats:italic>Ab<\/jats:italic> (62.5% vs. 15.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004). Significant differences were found in the need for renal replacement therapy (75% vs. 17.2%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), catecholamine use (100% vs. 54.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) and use of invasive mechanical ventilation (100% vs. 62.7%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Also, in the proportion of severe acute respiratory distress syndrome (62.5% vs. 23.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), septic shock (100% vs. 40.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and cardiogenic shock (87.5% vs. 15.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Compared to severe non\u2010<jats:italic>Ab\u2010<\/jats:italic>related CAP, severe CAP\u2010<jats:italic>Ab<\/jats:italic> is characterised by higher mortality, associated with a high frequency of multiple organ failure. Excessive alcohol consumption and malnutrition seem to be risk factors. To improve outcomes, broader spectrum antibiotic therapy must be immediately proposed when CAP\u2010<jats:italic>Ab<\/jats:italic> is suspected.<\/jats:p>","DOI":"10.1111\/tmi.14067","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T12:30:30Z","timestamp":1733315430000},"page":"43-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Severe community\u2010acquired pneumonia compared to severe community\u2010acquired <i>Acinetobacter baumannii<\/i> pneumonia in Reunion Island: A retrospective study"],"prefix":"10.1111","volume":"30","author":[{"given":"Giacomo","family":"Rotini","sequence":"first","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"de Mangou","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Combe","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Renou","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Combe","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radj","family":"Cally","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lagrange\u2010Xelot","sequence":"additional","affiliation":[{"name":"Department of infectious and tropical disease Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Allou","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Miltgen","sequence":"additional","affiliation":[{"name":"Department of microbiology, Felix Guyon University Hospital, UMR PIMIT, CNRS 9192, INSERM U1187, IRD 249 University of Reunion Island  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Vidal","sequence":"additional","affiliation":[{"name":"Department of intensive care medicine Felix Guyon University Hospital  Saint\u2010Denis Reunion France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-007-0365-6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.2015.1025055"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267184"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13137"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.23-0820"},{"key":"e_1_2_10_9_1","unstructured":"French ministry of health youth and sports.Technical committee of hospital\u2010acquired infection.2007. 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