{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:04:21Z","timestamp":1739855061311,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ocular infections can harm the eye's anatomic structure on numerous levels. They are a global health issue. Endophthalmitis, a serious complication following cataract surgery, can result in substantial ocular morbidity and vision loss despite the administration of antibiotics. Bacterial ocular flora are the primary causative agents. This study aimed to assess the types of bacterial isolates on the external ocular surface and evaluate their antimicrobial susceptibility patterns in pre\u2010operative cataract patients at Kafrelsheikh University Hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study enrolled 691 patients scheduled for routine cataract surgery in the Department of Ophthalmology at Kafrelsheikh University Hospitals, Egypt. Each patient underwent a comprehensive assessment of medical history, including the use of traditional medicine, past eye trauma, and any prior eye surgeries, as well as ophthalmic clinical data such as visual acuity and ocular surface disorders. Conjunctival swabs were collected and processed using standard microbiological procedures to identify bacterial isolates and their respective antimicrobial susceptibility patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 691 patients enrolled (median age 60\u2009years, IQR 54\u201366), 59.8% were female. Conjunctival cultures yielded positive results in 38 cases (5.6%). The most frequently isolated organisms were <jats:italic>Staphylococcus aureus<\/jats:italic>, accounting for 52.6% of isolates, followed by <jats:italic>Staphylococcus epidermidis<\/jats:italic> at 15.8%. Notably, <jats:italic>S. aureus<\/jats:italic> demonstrated the highest resistance to erythromycin and vancomycin, with all 20 isolates showing resistance. In contrast, linezolid exhibited high efficacy, with 19 isolates showing sensitivity and only one displaying resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicated that ocular conditions such as dry eye syndrome, Meibomian gland dysfunction, and scaly blepharitis are strongly associated with the prevalence of culture\u2010confirmed ocular infections. Regarding antibiotic susceptibility, most <jats:italic>Staphylococcus<\/jats:italic> species demonstrated the greatest sensitivity to linezolid and trimethoprim\/sulfamethoxazole.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14075","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T05:11:11Z","timestamp":1735189871000},"page":"118-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of bacterial isolates and antimicrobial susceptibility patterns in external ocular infections among patients attending eye clinic at Kafrelsheikh University Hospitals"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-2635","authenticated-orcid":false,"given":"Sally Hassan","family":"Essawy","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine Kafrelsheikh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1527-2282","authenticated-orcid":false,"given":"Mohamed Ahmed","family":"ELShafie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine Kafrelsheikh University  Kafr el\u2010Sheikh Egypt"},{"name":"Department of Ophthalmology, Faculty of Medicine New Mansoura University  New Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmeen Mohamed Mohamed","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Faculty of medicine, Kafr Elsheikh Kafrelsheikh University Hospital  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-7178","authenticated-orcid":false,"given":"Mo'men Mahmoud","family":"Saadoun","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Kafrelshiekh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0254-2992","authenticated-orcid":false,"given":"Nahla A.","family":"Nosair","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine Kafrelshiekh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebatalla Abdelmaksoud","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine Kafrelshiekh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4312-3194","authenticated-orcid":false,"given":"Ayat Shaban Mousa","family":"El Nahal","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine Kafrelsheikh University  Kafr el\u2010Sheikh Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"issue":"4","key":"e_1_2_14_2_1","first-page":"E408","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30\u2009years, and prevalence of avoidable blindness in relation to VISION 2020: the right to sight: an analysis for the global burden of disease study (vol 2, pg. 144, 2021)","volume":"9","author":"Steinmetz JD","year":"2021","journal-title":"Lancet Global Health"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40123-018-0141-y"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-017-0612-2"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9081550"},{"issue":"2","key":"e_1_2_14_6_1","article-title":"Postoperative endophthalmitis after cataract surgery: an update","volume":"14","author":"Althiabi S","year":"2022","journal-title":"Cureus"},{"issue":"1","key":"e_1_2_14_7_1","first-page":"869","article-title":"Bacterial spectrum of external ocular infections: prevalence and associated in vitro antimicrobial susceptibility and resistance in a tertiary care hospital","volume":"6","author":"Ahmed E","year":"2018","journal-title":"J Adv Res"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy381"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277230"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/MJBL.MJBL_558_23"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-018-3705-y"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46078-y"},{"key":"e_1_2_14_13_1","unstructured":"CLSI.Abbreviated Identification of Bacteria and Yeast: Approved Guideline 2nd Edition. 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