{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:10:31Z","timestamp":1773796231041,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:00:00Z","timestamp":1736380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["474796\/2012\u20104"],"award-info":[{"award-number":["474796\/2012\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["BPD\u201000394\u20102"],"award-info":[{"award-number":["BPD\u201000394\u20102"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to determine reference points for thermal perception in cutaneous lesions of leprosy, a disease caused by <jats:italic>Mycobacterium leprae<\/jats:italic> characterised by hypoesthesia in skin lesions due to nerve and Schwann cell infection. Early diagnosis is essential to control transmission and effectively treat the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Quantitative thermal testing (QTT) has been proposed as a valuable tool for early detection of the disease, initiation of treatment, and monitoring of nerve damage. A thermal analyser was used to determine warm and cold perception thresholds (WPT and CPT, respectively) in skin lesions of 42 leprosy patients and 22 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The thresholds were determined using a 0.25\u2009cm<jats:sup>2<\/jats:sup> thermal stimulator, the method of limits, and the receiver operating characteristic (ROC) curve. Thermal thresholds were higher in patients\u2019 skin lesions compared to unaffected areas and controls. The reference points calculated for the WPT and CPT were 36.55 and 26.35\u00b0C, respectively, with high sensitivity and specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The nerve fibres affected by leprosy caused altered thermal sensitivity in the patients\u2019 lesions, especially in warm sensation. A smaller thermal stimulator and the method of limits were effective in detecting early sensory deficits in nerve fibres, demonstrating the potential for early detection of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14079","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T02:03:34Z","timestamp":1736474614000},"page":"170-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of sensory deficits in fine nerve fibres in leprosy diagnosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Ismael Alves","family":"Rodrigues J\u00fanior","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Thereza","family":"Chaves","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Cardoso","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Lyon","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes  Belo Horizonte Minas Gerais Brazil"},{"name":"Faculdade de Sa\u00fade e Ecologia Humana (FASEH)  Vespasiano Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida","family":"de Faria Grossi","sequence":"additional","affiliation":[{"name":"Faculdade de Sa\u00fade e Ecologia Humana (FASEH)  Vespasiano Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramayana Morais","family":"de Medeiros Brito","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Parasitologia Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Laura Grossi","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel","family":"de Figueiredo Villarroel","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Ot\u00e1vio","family":"da Costa Rocha","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina Universidade Federal de Minas Gerais (UFMG)  Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"257","article-title":"Gerhard Henrik Armauer Hansen 1841\u20131912. 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