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The clinical\u2010epidemiologic analysis of hospital admissions is strategic due to limited data on chronic CD infections and the general lack of access to diagnosis and treatment. This study examines sociodemographic and clinical\u2010epidemiological patterns of hospital morbidity and mortality from CD and its temporal trends from 2000 to 2022 in Bahia, Northeast Brazil. A mixed ecological study was conducted using data from hospital and mortality information systems. We calculated the hospital case fatality and all\u2010cause mortality rates for CD, analysing temporal trends through\n                    <jats:italic>joinpoint<\/jats:italic>\n                    regression. Out of 20,189,658 hospital admissions, 4,557 (0.02%) were associated with CD, yielding a hospital lethality of 0.10 per 100,000 inhabitants. Of 1,832,325 Death Certificates, 16,960 (0.93%) were attributed to CD, equating to 5.16 deaths per 100,000 inhabitants. The risk ratios for hospital case fatality and mortality were higher among males, residents of municipalities with a \u2018medium\u2019 Brazilian Deprivation Index, those in the Central\u2010North region, and patients with megacolon. Hospital case fatality significantly increased among males, the elderly (\u226570\u2009years) and residents in municipalities with \u2018high\u2019 or \u2018very high\u2019 Brazilian Deprivation Index in the Central\u2010North and Central\u2010East regions. The all\u2010cause mortality trend for CD also rose among women and in municipalities with \u2018high\u2019 and \u2018very high\u2019 Brazilian Deprivation Index across the Southwest, West, North and Central\u2010East regions. Programmatic vulnerabilities related to healthcare access within the Unified Health System likely contributed to delayed diagnoses and the increasing severity of specific forms of CD.\n                  <\/jats:p>","DOI":"10.1111\/tmi.14085","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T03:25:27Z","timestamp":1742181927000},"page":"368-381","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High burden of hospital morbidity and mortality due to Chagas disease in Bahia state, Northeast Brazil, 2000\u20132022"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-4721","authenticated-orcid":false,"given":"Gabriela Soledad M\u00e1rdero","family":"Garc\u00eda","sequence":"first","affiliation":[{"name":"School of Medicine, Postgraduate Program in Public Health Federal University of Cear\u00e1  Fortaleza 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Lima","family":"Palmeira","sequence":"additional","affiliation":[{"name":"Department of Health Surveillance, General Coordination of Zoonosis and Vector\u2010Borne Disease Surveillance, Department of Immunization and Transmissible Diseases Ministry of Health  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-382X","authenticated-orcid":false,"given":"Cleudson Nery","family":"de Castro","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department University of Bras\u00edlia  Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0074-3392","authenticated-orcid":false,"given":"Cristiane Medeiros Moraes","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Health Department of the State of Bahia, Superintendence of Health Surveillance Epidemiological Surveillance Directorate  Bahia 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