{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T01:10:07Z","timestamp":1749085807458,"version":"3.41.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,6]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>During the 2014\u20132016 Ebola epidemic in West Africa and the Ebola outbreaks between 2018 and 2020 in the Democratic Republic of Congo, vaccines and other tools for prevention and treatment had to be taken through trials in exceptional circumstances using accelerated processes.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>We interviewed members of ethics committees, health authorities, health professionals, and political authorities in the Democratic Republic of Congo in 2021 and held a workshop with ethics committee members and regulatory authorities from Sierra Leone and Guinea in 2022 in order to document their experiences of reviewing, approving, and regulating current and new studies during epidemics and outbreaks, and to document lessons learnt and their recommendations for the rapid review of clinical trial protocols during public health emergencies.<\/jats:p><\/jats:sec>Results<\/jats:title>Similar barriers were identified in the three countries. These were related to weak legal frameworks and partnerships between ethics committees and regulatory bodies. Inadequate human resources, outdated standard operating procedures and guidelines, and lack of finance to support timely reviews were identified. We also noted a lack of awareness from politicians, scientists, and communities about the existence and functions of regulatory bodies\/ethics committees, a lack of independence, and low interest in research. Opportunities identified by the institutions in the countries concerned included training ethics committee members and networking with experienced international platforms like the African Vaccine Regulatory Forum. Laws on regulating research have been updated in Sierra Leone and in Guinea, but not yet in the Democratic Republic of Congo.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Regulatory bodies have been facing many challenges in terms of a lack of a legal framework, a lack of finance, and a lack of support from politicians, scientists, and communities. Networking has been an opportunity for these regulators to mitigate these impediments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.14111","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:51:51Z","timestamp":1743814311000},"page":"539-546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulator experiences of trials during Ebola epidemics in Sierra Leone, Guinea, and the Democratic Republic of the Congo"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5340-7048","authenticated-orcid":false,"given":"Kambale","family":"Kasonia","sequence":"first","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Baiden","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"},{"name":"University of Health and Allied Sciences Ho Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Le Marcis","sequence":"additional","affiliation":[{"name":"Ecole Normale sup\u00e9rieure de Lyon Lyon France"},{"name":"Universit\u00e9 de Montpellier, Institut de Recherche pour le D\u00e9veloppement, IRD Institut National de la Sante et de la Recherche M\u00e9dicale, INSERM Montpellier France"},{"name":"D\u00e9partement de Sciences Sociales, Centre de recherche et de formation en infectiologie de Guin\u00e9e CERFIG Republic of Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Lapika","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anthropologie Universit\u00e9 de Kinshasa Kinshasa The Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Kiyulu","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anthropologie Universit\u00e9 de Kinshasa Kinshasa The Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Kimina","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'Anthropologie Universit\u00e9 de Kinshasa Kinshasa The Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freddy","family":"Bikioli","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department Universit\u00e9 de Kinshasa Kinshasa The Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Attas","sequence":"additional","affiliation":[{"name":"Ecole Normale sup\u00e9rieure de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mansaray","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Burns","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elys\u00e9e","family":"Nouvet","sequence":"additional","affiliation":[{"name":"School of Health Studies Western University London Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9verine","family":"Thys","sequence":"additional","affiliation":[{"name":"Centre de Coop\u00e9ration Internationale en Recherche Agronomique pour le D\u00e9veloppement, CIRAD Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antea","family":"Paviotti","sequence":"additional","affiliation":[{"name":"University of Antwerp Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Manno","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukeh Kenneth","family":"Fahnbulleh","sequence":"additional","affiliation":[{"name":"Ministry of Health Freetown Sierra Leone"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailah","family":"Leigh","sequence":"additional","affiliation":[{"name":"College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Samai","sequence":"additional","affiliation":[{"name":"College of Medicine and Allied Health Sciences University of Sierra Leone Freetown Sierra Leone"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Greenwood","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Lees","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick Mitashi","family":"Mulopo","sequence":"additional","affiliation":[{"name":"Tropical Medicine Department Universit\u00e9 de Kinshasa Kinshasa The Democratic Republic of the Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Watson\u2010Jones","sequence":"additional","affiliation":[{"name":"London School of Hygiene & Tropical Medicine London UK"},{"name":"Mwanza Intervention Trials Unit National Institute for Medical Research Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"History of Ebola Disease Outbreaks | History | Ebola (Ebola Virus Disease) | 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