{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:02:28Z","timestamp":1793826148849,"version":"4.6.1"},"reference-count":91,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the social and economic impacts and disease burden of Chikungunya Fever globally through a systematic literature review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a comprehensive literature search through MEDLINE (via PubMed), LILACS, and Embase databases, and grey literature, including studies of populations diagnosed with Chikungunya Fever or at risk of infection published in English, Spanish, French, or Portuguese, without date restrictions. Two reviewers independently performed study selection, data extraction, and quality assessment. Methodological quality was assessed using different tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty\u2010three publications were included. Until 2013, publications originated solely from the Asian and African continents. From 2015 onwards, South America emerged as the predominant source. Publications were classified as cost studies (25), including cost\u2010of\u2010illness (18) and program cost (6); burden of disease studies (10); cost\u2010outcome studies (4), including cost\u2010effectiveness (3) and cost\u2010utility (1); and quality\u2010of\u2010life studies (15). Reported total direct costs associated with Chikungunya Fever ranged from US$ 3.5 million (US Virgin Islands, 2014\u20132015) to US$ 83.6 billion (Region of the Americas, 2013\u20132015). Direct medical costs varied from US$ 308.94 (Tamil Nadu, India, 2006) to US$ 33.7 million (R\u00e9union Island, 2005\u20132006). Vector control program costs ranged from US$ 888,000 annually (Greece, 2013\u20132017) to US$ 466 million (Brazil, 2016). Estimated disability\u2010adjusted life years per 100,000 population ranged from 4.53 (India, 2006) to 2432 (Region of the Americas, 2013\u20132015). Quality\u2010of\u2010life studies demonstrated substantial declines across multiple domains, indicating significant functional impairment due to Chikungunya Fever.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chikungunya Fever imposes a considerable economic and social burden, surpassing that of other endemic arboviral diseases such as dengue and yellow fever. These findings underscore the need for further research to accurately quantify the full scope of Chikungunya Fever\u2010related costs and impacts on affected populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70012","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T07:59:41Z","timestamp":1753171181000},"page":"865-892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Burden of Chikungunya Fever and Its Economic and Social Impacts Worldwide: A Systematic Review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-7238","authenticated-orcid":false,"given":"Vaneide Daciane","family":"Ped\u00ed","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz  Bras\u00edlia Federal District Brazil"},{"name":"Faculdade de Medicina, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Medicina Tropical Universidade de Bras\u00edlia  Bras\u00edlia Federal District Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-2017","authenticated-orcid":false,"given":"Giovanny Vin\u00edcius Ara\u00fajo","family":"de Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Sa\u00fade do Brasil, Secretaria de Ci\u00eancia, Tecnologia e Inova\u00e7\u00e3o e do Complexo Econ\u00f4mico Industrial da Sa\u00fade, Departamento de Ci\u00eancia de Tecnologia  Bras\u00edlia Federal District Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-820X","authenticated-orcid":false,"given":"Viviane Bellini","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Departamento de Nutri\u00e7\u00e3o Universidade de Bras\u00edlia  Bras\u00edlia Federal District Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-8103","authenticated-orcid":false,"given":"Felipe Tavares","family":"Duailibe","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Excellence in HIV\/AIDS  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8224-6038","authenticated-orcid":false,"given":"Marcella T. 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