{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:33:04Z","timestamp":1773005584615,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Irritable bowel syndrome (IBS) is associated with impaired quality of life (QoL), anxiety and depression. Intestinal parasitic infections may exacerbate this burden, but their impact on psychological and functional outcomes remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this Phase II case\u2013control study, 100 IBS patients and 100 age\u2010 and sex\u2010matched healthy controls were assessed using a 36\u2010item disease\u2010specific QoL questionnaire and the Hospital Anxiety and Depression Scale (HADS). IBS patients were categorised as parasite\u2010negative or parasite\u2010positive (\n                      <jats:styled-content style=\"fixed-case\">Giardia lamblia<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">Entamoeba histolytica<\/jats:styled-content>\n                      ). Subgroup analyses examined the effect of parasitic infection on QoL and psychological outcomes. Correlations between HADS scores and QoL were evaluated using Pearson's coefficient.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IBS patients exhibited significantly higher anxiety (13.8\u2009\u00b1\u20094.5 vs. 8.5\u2009\u00b1\u20094.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and depression (13.7\u2009\u00b1\u20094.4 vs. 6.9\u2009\u00b1\u20093.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) scores compared to controls. QoL scores were lowest in\n                      <jats:styled-content style=\"fixed-case\">E. histolytica<\/jats:styled-content>\n                      \u2013infected patients (41.0\u2009\u00b1\u20099.1), intermediate in\n                      <jats:italic>Giardia<\/jats:italic>\n                      \u2013infected patients (54.5\u2009\u00b1\u20098.5) and highest in parasite\u2010free IBS patients (72.0\u2009\u00b1\u20097.2). HADS anxiety (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and depression (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.58,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) correlated negatively with QoL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>IBS is associated with substantial psychological morbidity and QoL impairment, both of which are exacerbated by intestinal parasitic infection. These findings highlight the importance of addressing both infection and psychological health in comprehensive IBS management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.70079","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T05:21:17Z","timestamp":1769232077000},"page":"374-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life and Psychological Burden in Irritable Bowel Syndrome: The Impact of Intestinal Parasitic Infections (Phase\n                    <scp>II<\/scp>\n                    Study)"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-2591","authenticated-orcid":false,"given":"Nourhan","family":"Badwei","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine, Gastroenterology and Hepatology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Environment, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghada O.","family":"Wassif","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine and Environment, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala E. Shams","family":"El\u2010Din","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.099"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.04.014"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1607547"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.032"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010020\u20100286\u20108"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i10.2456"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100447.1983.tb09716.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102020\u2010321191"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2011.06643.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102011\u2010300220"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.70660"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3071"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.014"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.76158"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu629"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw621"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.8974"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2022.2158656"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40475\u2010024\u201000314\u20102"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41395\u2010018\u20100222\u20105"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70079","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tmi.70079","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:09:24Z","timestamp":1772996964000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,23]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/tmi.70079"],"URL":"https:\/\/doi.org\/10.1111\/tmi.70079","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,23]]},"assertion":[{"value":"2025-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}